Cardiopulmonary Disease, Fluid Overload
Conditions
Brief summary
Evaluation of fluid status in cardiac surgery patients using bioelectrical impedance and its impact on postoperative morbidity and mortality
Detailed description
Hydration and fluid balance dynamics after cardiac surgery is complex and requires comprehensive knowledge of bluid balance dynamics. Surgical trauma, anaesthesia and use of cardiopulmonary bypass significantly influence postoperative fluid status. Deviations from normal values on the other hand can be related to increase in morbidity and mortality. The purpose of this prospective observational clinical study is to assess fluid status using bioelectric impedance in patients undergoing cardiac surgery and to evaluate its impact on postoperative morbidity and mortality.
Interventions
DIAGNOSTIC_TESTBioelectrical impedance
Fluid distribution measured by bioelectrical impedance Bodystat Multiscan 5000 Bodystat Ltd, Isle of Man, British Isles
Sponsors
University Medical Centre Ljubljana
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Elective cardiovascular surgery (on-pump or off-pump) 2. Age ≥ 18 years 3. ASA 3 or 4 4. Provided verbal and written informed consent
Exclusion criteria
1. Refusal to participate in the research 2. \< 18 years 3. Renal failure requiring replacement treatment with hemodialysis 4. Amputation of a limb 5. Pregnancy 6. Emergency Procedures 7. Reoperation 8. Pacemaker/implantable cardioverter-defibrillator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fluid distribution during the early postoperative period (≤ 5 days) | Perioperative period (preoperatively, on the first, third, and fifth postoperative day) | Phase angle (in degrees) |
Secondary
| Measure | Time frame |
|---|---|
| Impact of fluid distribution/fluid overload on postoperative complications (myocardial infarction, cardiogenic shock, vasoplegia, atrial fibrillation, heart failure, bleeding, infections, delirium) | Up to 1 year after the operation |
| Impact of fluid distribution/fluid overload on length of stay in the intensive care unit | Duration of stay in ICU (estimated to up to 5 days) |
| Impact of fluid distribution/fluid overload on duration of postoperative mechanical ventilation | Duration of stay in ICU (estimated to up to 5 days) |
| Impact of fluid distribution/fluid overload on 30-day postoperative mortality | On day 30 |
| Impact of fluid distribution/fluid overload on 1-year postoperative mortality | At 1 year postoperatively |
| Impact of fluid distribution/fluid overload on length of hospitalisation | Duration of hospital stay (up to 1 month) |
Countries
Slovenia
Contacts
Primary ContactLaura Kekec
Outcome results
None listed