Maternal Hypotension
Conditions
Keywords
norepinephrine, maternal hypotension
Brief summary
Norepinephrine has emerged as a potential alternative for stabilizing blood pressure during spinal anesthesia for cesarean section, purportedly maintaining maternal heart rate and cardiac output more effectively than phenylephrine. However, its application as an intravenous bolus for treating hypotension remains underexplored. Consequently, this current investigation aimed to determine the ED50 and ED95 of norepinephrine for managing maternal hypotension during cesarean section. A prospective trial enrolled 100 patients undergoing elective delivery under spinal anesthesia, with norepinephrine dosage determined using the upper and lower sequential distribution method (UDM).
Interventions
DRUGNorepinephrine
Participants in this arm will receive norepinephrine as a bolus dose to treat maternal hypotension during cesarean section under spinal anesthesia. The dosage will be determined using the upper and lower sequential distribution method (UDM). The aim is to investigate the effective dose (ED50 and ED95) of norepinephrine in maintaining maternal blood pressure stability and optimizing maternal outcomes during the procedure.
Sponsors
The Third People's Hospital of Bengbu
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria included women undergoing elective caesarean section undergoing combined lumbar and rigid anaesthesia, healthy singleton pregnancies at full term (more than 37 weeks gestation), American Society of Anaesthesiologists physical status I or II, body weight between 50-100 kg, height between 150-180 cm, and fasting for more than 8 hours.
Exclusion criteria
The
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intravenous norepinephrine to maintain maternal systolic blood pressure 80% above baseline before fetal delivery. | From the initiation of anesthesia to the delivery of the fetus. | Intravenous norepinephrine pumped to maintain maternal systolic blood pressure 80% above its basal value prior to delivery of the foetus |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative adverse reactions | Perioperative period | Dizziness, chest tightness, nausea, vomiting, bradycardia, secondary hypertension and other adverse reactions |
| Number of remedial drugs | Perioperative period | Includes incidence of remedial use of atropine, incidence of remedial use of norepinephrine. |
| Neonatal Apgar score | Immediately After delivery of the foetus | Neonatal 1-min and 5-min Apgar scores |
Countries
China
Contacts
Primary ContactChengfei Xu
Outcome results
None listed