Enteropathy, Growth Failure
Conditions
Brief summary
The study was conducted on 200 patients with growth faltering on 2 phases. In the first phase the patient received nutritional rehabilitation with polymeric formula for 12 weeks then they were reassessed by anthropometric measurements and those whose weight remained below -2 SD for age and sex on the WHO scores were defined as non responders and entered the second phase. In the second phase Upper Gastrointestinal endoscopy was done and then patients received nutritional rehabilitation with peptide based formula and probiotics then were reassessed after 8 weeks.
Interventions
DIETARY_SUPPLEMENTpolymeric formula
Patients with growth faltering received nutritional rehabilitation with polymeric formula and were reassessed after 12 weeks by anthropometric measurements
DIETARY_SUPPLEMENTpeptide based formula
patients who were defined as non responders and underwent upper gastrointestinal endoscopy and diagnosed as environmental enteropathy, received nutritional rehabilitation with peptide based formula
Sponsors
Ain Shams University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Patient with growth faltering whose weight still below -2 SD for age and sex on the WHO scores after 12 weeks of nutritional rehabilitation with polymeric formula, underwent upper gastrointestinal endoscopy and who were diagnosed as environmental enteropathy, received nutritional rehabilitation with peptide based formula and probiotics
Eligibility
Sex/Gender
ALL
Age
6 Months to 5 Years
Healthy volunteers
No
Inclusion criteria
* Patients whose weight below -2 SD for age and sex on the WHO scores.
Exclusion criteria
* Secondary cases of malnutrition or undernutrition. * Patients with symptoms of GIT problems as chronic vomiting, chronic or bloody diarrhea, chronic abdominal distension, hematemesis or bleeding per rectum. * Patients who can't commit to a follow up visit every two weeks.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of the prevalence of environmental enteropathy among children with faltering growth. | 12 weeks of nutritional rehabilitation with polymeric formula. | Assess the number of patients whose weight still below -2SD and upper gastrointestinal endoscopy showed the criteria of environmental enteropathy. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Determine the increase in weight of children with growth faltering and environmental enteropathy after nutritional rehabilitation with peptide-based formula. | 8 weeks of nutritional rehabilitation with peptide-based formula. | Weight z- score |
Countries
Egypt
Outcome results
None listed