Role of Diffusion Weighted Image in the Diagnosis and Follow up of Breast Cancer

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06494865

Enrollment

Registered

2024-07-10

Start date

2024-08-01

Completion date

2024-12-01

Last updated

2024-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Brief summary

Breast MRI has become an important tool for breast cancer detection and characterization.Contrast enhanced MRI(CE-MRI) is currently the most sensitive detection technique for diagnosis of breast cancer.

Detailed description

Most of the lesions that occur in the breast are benign lesions. It is important to recognize benign lesions and distinguish them from breast cancer. Nowadays sonomammography still represents the primary imaging modality utilized for breast cancer screening and diagnosis. Breast MRI has become an important tool for breast cancer detection and characterization.Contrast enhanced MRI(CE-MRI) is currently the most sensitive detection technique for diagnosis of breast cancer.Diffusion weighted imaging provides micro-structural informations regadrding the diffusion of the water molecules in the tissue cellularity and tissue structure by using the quantitive analysis with the apparent diffusion coefficient (ADC) values. Using Diffusion weighted imaging (DWI) combined to MRI is helpful to distinguish malignant versus benign breast lesions and it also may reduce the number of unnecessarily breast biopsies.

Interventions

DEVICEMRI device

Standered breast coils with small field of veiw and thin sections will be used for the examinatio. MRI breast including Axial T1WI, T2WI Stir contrast DWI and Stir sagittal T1WI with contrast traction and subtraction

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 70 Years

Inclusion criteria

* \* Female gender * Age more than 18 years * Patients presented with breast lump * Patients with recurrent breast cancer following chemotherapy or radiotherapy sessions.

Exclusion criteria

* Male gender * Age younger than 18 years * Patients with recent breast trauma in the same diseased breast within the last 6 months * Lactating female presented with acute symptoms as trauma or breast abscess * Contraindication to perform MRI examination .these include : Cardiac pacemaker -Metallic aneurysm clips

Design outcomes

Primary

Measure	Time frame	Description
Rate of correlated false positive results of MRI DWI for the lesion with the positive results by histopathology.	6 months	evaluation of the lesion with MRI DWI and histopathology for detect rate of false posive results

Contacts

Primary ContactMennatullah A Ibrahim, resident

menaashraf@med.sohag.edu.eg01015003865

Backup ContactMedhat I Mohammed, professor

01014005636

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026