Placenta Accreta Spectrum
Conditions
Brief summary
Objectives: To evaluate the effect of oxytocin in reducing intraoperative blood loss in patients with PAS disorders planned for cesarean hysterectomy.
Interventions
DRUGoxytocin
Uterotonics will be given in the form of an IV bolus of 10 units of oxytocin immediately with the uterine incision
OTHERplacebo
IV bolus of normal saline immediately with the uterine incision
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnancy of singleton living fetus * Previous one or more cesarean sections * Gestational age: \> 32 weeks * The following ultrasound markers such as loss of clear retroplacental translucency, myometrial thinning, abnormal lacunae, irregular bladder wall, utero-vesicalhypervascularity. * Preoperative hemoglobin more than 10 gm/dl * Cases with PAS that will undergoing CS Hysterectomy
Exclusion criteria
* Maternal medical disorders e.g.: coagulation defects, cardiac diseases etc.…. * Any known or reported hypersensitivity to the used medication. * All cases with spontaneous placental separation at laparotomy. * All patients undergoing conservative management of PAS. * All cases which necessitate emergency termination.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative blood loss | during operation | amount of intraoperative blood loss in patients with PAS disorders undergoing cesarean hysterectomy |
Secondary
| Measure | Time frame |
|---|---|
| operative time | during operation |
Countries
Egypt
Contacts
Primary ContactAbdalla Mousa
Outcome results
None listed