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Comparison of Flow Controlled Ventilation and Volume Controlled Ventilation

Comparison of Flow Controlled Ventilation and Volume Controlled Ventilation in Microscopic Laryngeal Surgeries, a Randomized Controlled Trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06493162
Enrollment
68
Registered
2024-07-09
Start date
2024-08-01
Completion date
2026-02-01
Last updated
2026-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vocal Cord Disease, Vocal Cord Cyst

Keywords

Microscopic Laryngeal Surgery, Flow Controlled Ventilation, Volume Controlled Ventilation

Brief summary

Flow-Controlled Ventilation is designed to ventilate the patient with constant flows during both inspiration and expiration. During inspiration, the pressure rises linearly from a set positive end-expiratory pressure (PEEP) to a set positive inspiratory pressure (PIP), and then falls linearly from PIP to end-expiratory pressure (EEP) during expiration. There are no flow interruptions during the Flow-Controlled Ventilation cycle, and the rate of change of pressure and volume in the lungs is equal, allowing for higher tidal volumes at lower pressures. The user sets the inspiratory flow rate and the ratio of inspiratory to expiratory time, providing full control over the ventilation cycle. However, this results in two unusual features: During inspiration, the ventilator creates positive pressure to direct gas into the patient's lungs through the endotracheal tube (ETT). When the intratracheal pressure (airway pressure) reaches the set PIP value, the ventilator switches from inspiration to expiration. By reversing the flow, it utilizes the Bernoulli effect to create negative pressure, facilitating expiration. Despite the presence of negative pressure on the ventilator side, the pressure in the patient's airway remains positive at all times. Volume-controlled ventilation is a mode that is volume-controlled, time-cycled, time-triggered, and pressure-limited. In volume-controlled ventilation, high pressures are sometimes necessary to reach the target tidal volume. This can lead to barotrauma, atelectrauma, and volutrauma in the lungs. Therefore, to avoid high pressures, low tidal volume ventilation is preferred. For Microscopic Laryngeal Surgeries, patients are intubated with a small sized endotracheal tube which results with higher pressures. We think that flow controlled ventilation will improve the ventilation during the surgery with lower pressures.

Interventions

PROCEDUREIntubation

Patients will be intubated with 5mm sized endotracheal tube for microscopic laryngeal surgery

Patients in FCV group will be ventilated with flow controlled ventilation mode

Patients in VCV group will be ventilated with volume controlled ventilation mode

Sponsors

Kocaeli University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* Patients who undergo elective microscopic laser surgery * ASA status I and II

Exclusion criteria

* Surgery time more than 2 hours * Patients with difficult intubation * Patients with chronic lung diseases * BMI \> 25

Design outcomes

Primary

MeasureTime frameDescription
PIP10 minutes interval after the intubation during the surgeryPeak inspiratory pressure
RR10 minutes interval after the intubation during the surgeryRespiratory rate
TV10 minutes interval after the intubation during the surgeryTidal volume
Compliance (Cdyn)10 minutes interval after the intubation during the surgeryDynamic compliance (ventilator calculates: Cdyn = tidal volume/(PIP - PEEP)
Resistance10 minutes interval after the intubation during the surgeryResistance (ventilator calculates: dividing the \[peak pressure minus the plateau pressure\] by the flowrate in litres per second)

Secondary

MeasureTime frameDescription
HR10 minutes interval after the intubation during the surgeryHeart rate
MP10 minutes interval after the intubation during the surgeryMean blood pressure
SpO210 minutes interval after the intubation during the surgeryOxygen saturation

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026