Liver Function Abnormalities in Patients With Acute Heart Failure

Liver Function Abnormalities in Patients With Acute Heart Failure in Sohag University Hospitals

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06491628

Enrollment

100

Registered

2024-07-09

Start date

2024-07-01

Completion date

2025-08-31

Last updated

2024-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Heart Failure

Keywords

LFTs, AHF

Brief summary

The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients

Detailed description

Cardiac failure has a negative impact on the function of all parenchymatous organs, based both on the low organ perfusion in the left-sided failure and on the venous congestion in the right-sided failure. The pathophysiology of acute heart failure (AHF) is complex and not fully understood. It has been hypothesized that an episode of acute decompensation affects not only the cardiovascular system itself, but may also deteriorate the function of other organs, c ausing serious clinical consequences. Liver involvement has been mostly described and investigated in patients with chronic HF. Liver enzyme alterations are usually classified as relating predominantly to liver cell necrosis (signified by transaminase elevations) or predominantly to cholestasis (signified by elevated alkaline phosphatase (AP) level).

Interventions

BEHAVIORALAvoiding the risk factors

Exercise, Salt and lipid reduction in diet, smoking cessation

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Inclusion criteria

* patients aged 18 yrs or older presenting with AHF

Exclusion criteria

* Congenital heart disease * acute and chronic liver diseases

Design outcomes

Primary

Measure	Time frame	Description
Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals	baseline	assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

Secondary

Measure	Time frame	Description
Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals	1 year	assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

Countries

Egypt

Contacts

Primary ContactSara Mohamed

Sara_mohamed_post@med.Sohag.edu.eg+201117517685

Backup ContactHassan Ahmed

+201003459741

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026