ICH - Intracerebral Hemorrhage
Conditions
Brief summary
This study aim to develop inflammatory score based on proper integration of several inflammatory markers and investigate whether it was associated with hematoma expansion and poor outcomes in patients with ICH .
Detailed description
Intracerebral hemorrhage(ICH) accounts for approximately a quarter of all stroke subtypes with high mortality and the survi- vors always have varying degrees of residual disability. However, few medical and surgical treatments are clearly beneficial comparing with ischemic stroke. Hematoma expansion, which is a determinant of poor outcomes, occurs in about 30% of ICH patients especially at the early stage. Attenuating hema- toma expansion is a compelling target for ICH treatment, while the outcomes have not been accordingly improved after curbing the growth of hematoma in several clinical trials. It will be more helpful if a predictor can identify the risk of hematoma expansion and poor outcome rapidly and accurately. Thus the antiexpansion treatment to the patients with positive of such predictor is likely to provide clinical benefits.
Interventions
RADIATIONCT Brain
Patient needs follow up ct brain , cbc , CRP
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* patients having spontaneous ICH aged 18 years or older admitted to a stroke unit within 24 hours After symptom onset .
Exclusion criteria
1- patient have secondary ICH (cerebral aneurysm, Moyamoya syndrome, arteriovenous malformation, tumor, trauma or hemorrhagic transformation from brain infarction); (2)patient have primary intraventricular hemorrhage (IVH); (3)patients with historical modified Rankin scale (mRS) score greater than 1 (4) patient refused to be enrolled.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| primary (main): appropriate predictor of hematoma expansion and poor outcomes with good accuracies. | Baseline | The current study suggests inflammatory score consisting of appropriate integration of NLR, PLR, MLR, SII, LDH, and CRP is independently associated with hematoma expansion and poor outcomes of different terms in ICH patients, including secondary neurological deterioration within 48 hours, 30-day mortality, and 3-month poor mRS. Moreover, inflammatory score greater than or equal to 5 is validated as an appropriate predictor of hematoma expansion and poor outcomes with good accuracies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Secondary outcome | One year | Secondary (subsidiary) : 1. inflammatory score based on proper integration of several inflammatory markers 2. investigate whether it was associated with hematoma expansion in patients with ICH Helping . in better outcome and good prognosis 3. prediction of secondary neurological deterioration within 48 hours, 30-day mortality, and 3- month poor mRS Secondary (subsidiary) : 1. inflammatory score based on proper integration of several inflammatory markers 2. investigate whether it was associated with hematoma expansion in patients with ICH Helping . in better outcome and good prognosis 3. prediction of secondary neurological deterioration within 48 hours, 30-day mortality, and 3- month poor mRS |
Contacts
Primary ContactAhmed H. Abd El-samee, Master
Outcome results
None listed