High Altitude Pulmonary Hypertension, Sleep Apnea
Conditions
Keywords
high altitude illness, pulmonary hypertension, sleep apnea, disease progression, hypoxia
Brief summary
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participate din the study in 2017 to undergo follow-up examinations in 2024, in order to allow comparisons of current results with baseline data from 2017.
Interventions
None listed
Sponsors
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Permanently living \>2500 m * Written informed consent
Exclusion criteria
* Highlanders who cannot follow the study investigations, * Patients with moderate to severe concomitant lung disease (FEV1\<70% or forced vital capacity \<70%), severe parenchymal lung disease, heavy smoking \>20 cigarettes/day or \>20 pack-years. * Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months * Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in pulmonary artery pressure in highlanders | Year 2017 to 2024 | Change in pulmonary artery pressure (RV/RA measured by echocardiography) from 2017 to 2024 in highlanders living above 2500 m. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in TRP/CO in highlanders | Year 2017 to 2024 | Change in TRP/CO slope from 2017 to 2024 in highlanders living above 2500 m. |
| Progression of oxygen desaturation index | Year 2017 to 2024 | Change in the oxygen desaturation index from 2017 to 2024 in highlanders. |
| Change in pulmonary artery pressure between highlanders and lowlanders | Year 2017 to 2024 | Difference in the change in pulmonary artery pressure (RV/RA measured by echocardiography) from 2017 to 2024 between highlanders and lowland controls. |
| Progression of arterial blood gases | Year 2017 to 2024 | Change in the arterial blood gases from 2017 to 2024 in highlanders. |
| Progression of right heart strain | Year 2017 to 2024 | Change in the right heart strain from 2017 to 2024 in highlanders. |
| Progression of quality of life | Year 2017 to 2024 | Change in the mental and physical component score of the SF-36 questionnaire from 2017 to 2024 in highlanders. |
Contacts
Primary ContactSilvia Ulrich, Prof. Dr.
Backup ContactMichael Furian, Prof. Dr.
Outcome results
None listed