High Altitude Pulmonary Hypertension
Conditions
Keywords
Pulmonary Hypertension, Hypoxia, High Altitude, 6-Minute Walk Test
Brief summary
To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live \>2500m on 6-minute walk distance (6MWD)
Detailed description
This research in highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA \>30 mmHg who permanently live at HA \>2500 m will perform a 6-minute walk distance test near their living altitude in Aksay at 3200 m and on day 2 and 7 at 760 m after relocation
Interventions
6-minute walk test (6MWT) will be performed according to clinical standards
Sponsors
University of Zurich
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Each highlander with HAPH will perform a 6 MWT at 3200 m and at 760 m according to a prospective study design
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Permanently living \>2500 m * HAPH diagnosed with a minimum RV/RA of 30 mmHg assessed by echocardiography at an altitude of 3200 m * Written informed consent
Exclusion criteria
* Highlanders who cannot follow the study investigations, * Patients with moderate to severe concomitant lung disease (FEV1\<70% or forced vital capacity \<70%), severe parenchymal lung disease, heavy smoking \>20 cigarettes/day or \>20 pack-years. * Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months * Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 6-minute walk distance (6MWD) on day 2 of relocation to 760 m | day 2 at 760 m compared to 3200 m | Change in 6MWD in meter between LA (760 m) vs HA (3200 m) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 6-minute walk distance (6MWD) on day 7 of relocation to 760 m | day 7 at 760 m compared to 3200 m | 6-minute walk distance (6MWD) in meter between LA (760 m) and HA (3200 m) |
| Arterial oxygen saturation by pulseoximetry (SpO2) at rest and at peak 6MWD on day 2 of relocation to 760 m | day 2 at 760 m compared to 3200 m | Change in SpO2 in % between LA (760 m) vs HA (3200 m) |
| Arterial oxygen saturation by pulseoximetry (SpO2) at rest and at peak 6MWD on day 7 of relocation to 760 m | day 7 at 760 m compared to 3200 m | Change in SpO2 in % between LA (760 m) vs HA (3200 m) |
| Heart rate at rest and at peak 6MWD on day 2 of relocation to 760 m | after the first night at LA (760 m) | Change in hear rate in bpm between LA (760 m) vs HA (3200 m) |
| Heart rate at rest and at peak 6MWD on day 7 of relocation to 760 m | day 7 at 760 m compared to 3200 m | Change in hear rate in bpm between LA (760 m) vs HA (3200 m) |
| Blood pressure at rest and at 6MWD on day 2 of relocation to 760 m | day 2 at 760 m compared to 3200 m | Change in blood pressure in mmHg between LA (760 m) vs HA (3200 m) |
| Blood pressure at rest and at 6MWD on day 7 of relocation to 760 m | day 7 at 760 m compared to 3200 m | Change in blood pressure in mmHg between LA (760 m) vs HA (3200 m) |
| Borg Dyspnea scale at end 6MWT on day 2 of relocation to 760 m | day 2 at 760 m compared to 3200 m | Change of the Borg CR10 dyspnea scale at end of the 6MWT after the first night at LA (760 m) vs HA (3200 m) |
| Borg Dyspnea scale at end 6MWT on day 7 of relocation to 760 m | day 7 at 760 m compared to 3200 m | Change of the Borg CR10 dyspnea scale at end of the 6MWT after seven nights at LA (760 m) vs HA (3200 m) |
| Borg leg fatigue scale at end 6MWT on day 2 of relocation to 760 m | day 2 at 760 m compared to 3200 m | Change of the Borg CR10 leg fatigue scale at end of the 6MWT after the first night at LA (760 m) vs HA (3200 m) |
| Borg leg fatigue scale at end 6MWT on day 7 of relocation to 760 m | day 7 at 760 m compared to 3200 m | Change of the Borg CR10 leg fatigue scale at end of the 6MWT after seven nights at LA (760 m) vs HA (3200 m) |
Countries
Kyrgyzstan
Contacts
PRINCIPAL_INVESTIGATORTalant M Sooronbaev, Prof. Dr.
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
PRINCIPAL_INVESTIGATORSilvia Ulrich, Prof. Dr.
University Hospital Zurich, Department of Pulmonology
Outcome results
None listed