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Creatine Supplementation At Simulated Altitude

Creatine Supplementation At Simulated Altitude

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06489587
Enrollment
60
Registered
2024-07-08
Start date
2024-06-25
Completion date
2026-06-30
Last updated
2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Performance

Brief summary

Creatine supplementation has been shown to increase exercise performance at sea level. The goal of this study is to determine the effects of creatine supplementation on exercise performance at simulated altitude.

Detailed description

Military personnel often encounter harsh environments such as high altitudes and hypoxic conditions, leading to significant constraints on their exercise capacity and performance. At sea-level creatine supplementation increases exercise performance; however no experimental studies have examined the effect of creatine supplementation at simulated altitude. The overall objective of this study is to investigate the effects of creatine supplementation on exercise performance, via a repeated sprints test (Wingate Test) after a 2-day supplementation period, compared to a placebo group.

Interventions

DIETARY_SUPPLEMENTPlacebo

Participants given 40 grams of glucose in total to be taken over 2 days, in 5-gram servings (4 capsules), 4 times per day.

DIETARY_SUPPLEMENTCreatine

Participants given 40 grams of creatine in total to be taken over 2 days, in 5-gram servings (4 capsules), 4 times per day.

Sponsors

California Polytechnic State University-San Luis Obispo
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Masking description

Research staff collecting data will be masked to intervention

Intervention model description

Randomized study to two arms: 1) creatine supplementation, 2) glucose supplementation

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* 18-40 years old * BMI 18.5 to 40 kg/m2 * Habitually active (\>150 minutes per week of moderate-vigorous physical activity)

Exclusion criteria

* Pregnant or trying to become pregnant * Recent use of creatine supplementation * Supplemental allergies

Design outcomes

Primary

MeasureTime frameDescription
Peak powerChange from baseline to 3 daysPeak power is measured in watts.

Secondary

MeasureTime frameDescription
Body WeightChange from baseline to 3 daysBody weight is measured in kilograms.
Relative peak powerChange from baseline to 3 daysRelative peak power is measured in watts per kilogram.
Mean powerChange from baseline to 3 daysMean power is measured in watts.
Relative mean powerChange from baseline to 3 daysRelative mean power is measured in watts per kilogram.
Fatigue indexChange from baseline to 3 daysFatigue index is measured in watts per second.

Countries

United States

Contacts

Primary ContactTodd Hagobian, PhD
thagobia@calpoly.edu8057567511

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026