Fecal Amino Acids，Gut Taste Receptors and Irritable Bowel Syndromes

Alterations in Nutrient-sensing Mechanisms May Play a Role in Symptom Generation in Patients With IBS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06489444

Enrollment

100

Registered

2024-07-08

Start date

2023-03-16

Completion date

2024-08-31

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome

Brief summary

Clinical data, fresh feces and intestinal mucosal tissues of patients with diarrheal IBS were collected. High performance liquid chromatography, immunohistochemistry and immunofluorescence were used to study the amino acid levels in feces of patients with IBS, the expression of taste receptors in intestinal mucosa, and the correlation between symptoms of abdominal pain and diarrhea and the expression of taste receptors, so as to obtain the conclusion that intestinal amino acid perception abnormalities exist in patients with IBS. And correlated with clinical symptoms.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with IBS who meet the Rome IV diagnostic criteria: 1. that is, recurrent abdominal pain, with symptoms occurring at least 1 day per week or at least 3 days per month on average in the last 3 months, combining 2 or more of the following: 1. related to defecation; 2. accompanied by changes in the frequency of bowel movements; 3. Accompanied by changes in fecal characteristics (appearance). (Symptoms appeared at least 6 months before diagnosis, and above diagnostic criteria were met in the last 3 months) 2. Age ≥18 years old.

Exclusion criteria

* 1\. History of celiac disease and other organic intestinal diseases, metabolic diseases (thyroid dysfunction, diabetes, etc.); (2) Serious neurological, mental and psychological diseases, or accompanied by serious organ dysfunction; 3. Abdominal surgery; 4. Pregnant, possible pregnant and lactating patients; 5. History of colonoscopy in the past 1 year; 6. Declined to participate in the study.

Design outcomes

Primary

Measure	Time frame	Description
Taste receptor expression was associated with symptom severity	1 year	The severity of symptoms was correlated with the expression of taste receptors
Association between fecal amino acid levels and symptom severity in patients	1year	The severity of symptoms was correlated with fecal amino acid

Countries

China

Contacts

Primary Contactwang jinhai

jinhaiwang@hotmail.com13609281113

Outcome results