Proximal Ureteral Stone, Urolithiasis
Conditions
Keywords
Proximal ureteral stones, Ho: YAG lithotripsy, Thulium Fiber laser (TFL) lithotripsy, Semirigid ureteroscopic lithotripsy
Brief summary
The efficacy of Ho: YAG and TFL combined with semirigid ureteroscopic treatment of proximal ureteral stones will be compared.
Detailed description
The target population of this study is patients with proximal ureteral stones who are scheduled to undergo semirigid ureteroscopic laser lithotripsy. After enrollment, the subjects will be randomly assigned to the semirigid ureteroscopic holmium laser (Ho: YAG) lithotripsy group and the semirigid ureteroscopic thulium fiber laser (TFL) lithotripsy group for surgical treatment. The subjects will be followed up after surgery, and the collected data will be summarized and analyzed after the study.
Interventions
DEVICEThulium Fiber laser (TFL) lithotripsy
Patients with proximal ureteral stones undergoing ureteroscopic lithotripsy using thulium laser lithotripsy.
DEVICEHo: YAG lithotripsy
Ho:YAG laser lithotripsy was used in patients with proximal ureteral stones undergoing ureteroscopic lithotripsy.
Sponsors
Zhongnan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
Patients and data analysts were blinded to the allocation measures.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. ≥18 years old; 2. patients diagnosed with unilateral proximal ureteral stones ≤2cm by computed tomography (CT)/Kidney and upper bladder (KUB) radiography who required surgery; 3. patients who volunteered to participate in this study.
Exclusion criteria
1. Unable to give informed consent; 2. Untreated urinary tract infection; 3. Pregnant women; 4. Known anatomical abnormalities (such as urinary diversion or ureteral stenosis); 5. Urothelial tumors, transplanted kidney stones, irreversible coagulopathy; 6. The semi-rigid ureteroscope cannot reach the stone site, ureteroscopy-negative stones, and stones can be removed directly without laser lithotripsy; 7. The researchers believe that they are not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stone-free rate (SFR) | 2-4 weeks after surgery | Stone-free rate (SFR) after single-session laser lithotripsy using a semirigid ureteroscope without an auxiliary procedure assessed by CT/X-ray at 2-4 weeks follow-up after laser lithotripsy. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Operative time | Immediately during surgery | the time of laser lithotripsy |
| Intraoperative complications | Immediately during surgery | bleeding, ureteral perforation, ureteral wall injury, or intraoperative adverse events leading to termination of surgery |
| Postoperative complications | 2-4 weeks after surgery | Occurrence of postoperative complications |
| Additional procedures | Intraoperatively and before removal of the Ureteral stents | If semi-rigid ureteroscopy combined with laser lithotripsy fails, it is converted to flexible ureteroscopy, PCNL, laparoscopic lithotomy. In addition, ESWL treatment is performed before the double-J stent is removed after surgery.lithotripsy, and postoperative ESWL treatment before removal of the ureteral stents, among others. |
Countries
China
Contacts
Primary ContactXinghuan Wang
Outcome results
None listed