Esrd
Conditions
Brief summary
Dialysis removes potentially harmful chemicals from the blood but can also remove potentially valuable chemicals. One potentially valuable chemical called ergothioneine, which comes from the diet, is low in the blood of people receiving dialysis. For this research study, the investigators hope to learn how well a daily ergothioneine supplement will replenish the levels in the blood of people with kidney failure.
Interventions
DIETARY_SUPPLEMENTErgothioneine
Participants will receive ergothioneine capsule daily for 12 weeks.
OTHERPlacebo
Participants will receive placebo capsule daily for 12 weeks.
Sponsors
Stanford University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* kidney failure receiving hemodialysis or peritoneal dialysis
Exclusion criteria
* blood transfusion within 90 days * taking supplements which contain ergothioneine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| erythrocyte levels of ergothioneine | weeks 1, 2, 4, 8, and 12 (while taking ergothioneine or placebo); and weeks 16 and 20 (after stopping ergothioneine or placebo) | ergothioneine levels will be measured in whole blood |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| plasma levels of ergothioneine | weeks 1, 2, 4, 8, and 12 (while taking ergothioneine or placebo); and weeks 16 and 20 (after stopping ergothioneine or placebo) | ergothioneine levels will be measured in plasma |
Countries
United States
Contacts
CONTACTTammy Sirich, MD
PRINCIPAL_INVESTIGATORTammy Sirich, MD
Stanford University
Outcome results
None listed