Cardiac Output, Low, Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea, Respiratory Failure Chronic
Conditions
Keywords
Respiratory Failure, Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea, Cardiac Output, stroke volume
Brief summary
Chronic effects of noninvasive ventilation on myocardial function in patients with obesity hypoventilation syndrome (OHS) are scarcely understood. The aim of the present study was to evaluate the long-term effects of volume-targeted bilevel-positive airway pressure ventilation (BiPAP) on cardiac parameters and myocardial biomarkers in patients with OHS.
Detailed description
Chronic effects of non- invasive ventilation on myocardial function in patients with obesity hypoventilation syndrome (OHS) are scarcely understood. The aim of the present study was to evaluate the long-term effects of volume-targeted bilevel-positive airway pressure ventilation (BiPAP) on cardiac parameters and myocardial biomarkers in patients with OHS. Clinically stable patients with OHS referred to the tertiary centre for the initiation of long-term BiPAP therapy were consecutively enrolled in the study. At baseline, all participants underwent overnight cardiorespiratory polygraphy. BiPAP therapy using volume-targeted spontaneous/timed mode delivered via an oro-nasal mask was initiated. Beat-to-beat noninvasive monitoring by impedance cardiography was used to assess heart function at baseline and after 3 and 12 months of BiPAP use. Serum troponin 1, N-Terminal Pro-B-Type Natriuretic Peptide (NTProBNP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were monitored. Potential risks and benefits comprise haemodynamic effects of NIV on cardiovascular parameters including cardiac output and stroke volume. The study started 06/2016 and enrolment was finalized in October 2018. The study was funded by grants from the Slovak Research and Development Agency under contract No. APVV-16-0158, and VEGA 1/0220/17 and 1/0393/22 of the Ministry of Education, Slovakia. The main investigator is Pavol Pobeha, MD, PhD, co author is Ivana Paranicova, MD, PhD and the corresponding author (study coordinator prof. Ruzena Tkacova, MD, PhD)
Interventions
PROCEDURENoninvasive ventilation volume targetted
he aim of the present study was to evaluate the long-term effects of volume-targeted bilevel-positive airway pressure ventilation (BiPAP) on cardiac parameters and myocardial biomarkers in patients with OHS
Sponsors
Pavol Jozef Safarik University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Clinically stable patients with OHS and severe hypercapnia during the daytime, referred to the tertiary clinic for the initiation of long-term NIV to alleviate chronic respiratory failure were consecutively enrolled to the study
Eligibility
Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
\- Clinically stable patients with OHS and chronic severe hypercapnia
Exclusion criteria
* inability to provide written informed consent * neuromuscular diseases * chest wall diseases * metabolic diseases * acute respiratory tract infection * chronic obstructive pulmonary disease (COPD) * systolic LV failure as evidenced by LV ejection fraction\<45% on echocardiography
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Impedance cardiography measured cardiac output | 12 months | Impedance cardiography measured cardiac output before and after effective treatment of respiratory failure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Impedance cardiography measured stroke volume | 12 months | Impedance cardiography measured stroke volume before and after effective treatment of |
Countries
Slovakia
Outcome results
None listed