Effect of Drug
Conditions
Brief summary
To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD)
Detailed description
ACEI slowing down the onset and the progression of dystrophinopathic cardiomyopathy. To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD
Interventions
Patients will be given captopril to see effect on global longitudinal strain
Sponsors
Ain Shams University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
6 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Genetically confirmed Duchenne myodystrophy (DMD) patients with abnormal GLS \< -18% with minimum age of 6 years old.
Exclusion criteria
* Any patient who refuses to sign an informed consent. * Contraindication to ACEI: hypersensitivity - renal impairment - bilateral renal artery stenosis - aortic valve stenosis - hyperkalemia - hypotension. * Reduced ejection fraction below 50%.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The impaired global longitudinal strain will change in echo in the number of participants with duchenne myodystrophy | 6 months | Impaired Global longitudinal strain will be changed in echo after 6 months of treatment with Captopril in patients with duchenne myodystrophy |
Countries
Egypt
Contacts
Primary ContactFatma Ebeid, MD
Backup ContactSandra M Mina
Outcome results
None listed