Kidney Diseases, Diastolic Heart Failure, Small Vessel Disease, Glaucoma
Conditions
Brief summary
To explore the distribution of retinal vasculature parameters in patients with different subtypes of cardiovascular and ocular disease.
Detailed description
In this interventional cohort study, the investigators aim to evaluate retinal vascular function as assessed by optical coherence tomography angiography, fundus photography and dynamic vessel analysis in patients who share microvascular involvement of their pathology (e.g. chronic kidney disease, cardiac decompensation, neuronal small vessel disease and glaucoma) and age-matched healthy controls. Plasm and skin samples for comparative proteomics and transcriptomics are also taken.
Interventions
DIAGNOSTIC_TESTOptical coherence tomography(-angiography) OCT(A)
OCTA is a non-invasive diagnostic tool capable of generating cross-sectional coupes of the retina and choroid. Novel algorithms allow to render a 3-dimensional model of the ocular microcirculation based merely on the motion contrast of the circulating blood.
DIAGNOSTIC_TESTFundus pictures
Visucam (Zeiss), Topcon NW8 fundus camera, NFC 600 (Crystalvue)
DIAGNOSTIC_TESTDVA 3.0
IMEDOS GmbH
DIAGNOSTIC_TESTHyperspectral retinal images
Ximea SNm4x4 hyperspectral snapshot camera
DIAGNOSTIC_TESTSphygmoCor
Sphygmocor Excell
DIAGNOSTIC_TESTSphygmomanometer
For the measurement of the blood pressure.
DIAGNOSTIC_TESTBlood sample
For both routine cardiovascular health biomarkers as well as genetic markers (DNA, mRNA, miRNA).
DIAGNOSTIC_TESTSkin biopsy
Spatial proteomics and transcriptomics for endothelial function.
DIAGNOSTIC_TESTNeuropsychological examination
Moca, Stroop color word test, concept shifting test, COWAT, (R)AVLT, Beck depression inventory, GDS
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adult patients with a confirmed or suspect diagnosis of glaucoma based on intra-ocular eye pressure, visual field defect and structural optic nerve changes, regardless their age. * Adult patients with chronic kidney disease regardless their age. * Adult patients with heart failure with preserved ejection fraction (HFpEF), regardless their age: symptomatic heart failure with Left Ventricle Ejection Fraction \> 50% AND BNP \> 35 pg/ml (or NT-proBNP\>125 pg/ml) OR signs of diastolic dysfunction according to the European Society of Cardiology guidelines 2016 * Adult patients with confirmed small vessel disease as is diagnosed on routine neurological imaging, regardless their age. * People without history or track record of any relevant pathology, including cardiovascular and renal diseases, regardless their age * Capable and willing to participate (informed consent)
Exclusion criteria
* Diabetes * Personal medical history of retinal neovascularization. * Unable or unwilling to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative distribution of retinal endothelial reactivity, flow index, vessel density in the different subpopulations. | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic performance of the aforementioned parameters to distinguish the different subpopulations. | 3 years |
| The association between these parameters and (1) the presence of risk factors for cardiovascular disease (including biomarkers) and (2) risk factors for disease progression and (3) neuropsychological functioning | 3 years |
| Physiological behaviour of retinal vasculature under cardiovascular stress. | 3 years |
| Histopathological correlates in dermal microvasculature | 3 years |
Countries
Belgium
Contacts
Primary ContactJan Van Eijgen, MD
Backup ContactSarah Spileers, SC
Outcome results
None listed