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Study of Intra- and Interpersonal Multimodal Synchronizations in a Social Interaction in Individuals with a Diagnosis of Schizophrenia.

Study of Multimodal Intra- and Interpersonal Synchronizations in Social Interaction in Individuals with a Diagnosis of Schizophrenia.

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06484387
Acronym
ENHANCER1
Enrollment
120
Registered
2024-07-03
Start date
2024-11-08
Completion date
2025-11-08
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Keywords

social interaction, interpersonal synchronization

Brief summary

The aim of this study is to precisely identify deficits in intra- and interpersonal multimodal synchronizations during social interaction in individuals with schizophrenia (ISZ). During a social interaction, individuals use both visual and auditory channels to construct their discourse. The auditory channel encompasses the semantics and prosody of the speech, while the visual channel describes the entirety of non-verbal gestures (e.g., facial expressions, body movements). Prosody and non-verbal gestures are essential elements for the speaker. By accompanying speech, they contribute to the planning and conceptualization of the utterance and enhance its communicative power. For the listener, prosody and non-verbal gestures are also used to provide sensory feedback to the speaker. Several studies have shown the existence of intrapersonal and interpersonal synchronizations of prosody and non-verbal gestures during interaction. These synchronizations are associated with numerous social benefits (e.g., increased mutual appreciation and quality of interaction). However, certain mental disorders, such as schizophrenia, exhibit deficits in non-verbal behaviors that can impair these synchronizations and the associated social benefits. We hypothetized that interaction with individuals with a daignosis of schizophrenia will be associated with deficits in intra and interpersonal synchronization.

Detailed description

This study includes a pre-inclusion interview followed by a visit to the university hospital (CHU) lasting about 2 hours (including a break). During the visit, the patient participates in an experimental protocol consisting of two parts. In the first part, the patient will be paired with an interaction partner, and the two participants will engage in four distinct conversational tasks, including getting to know each other, free discussions, structured dialogues, and emotional interactions. In the second part, the participants will answer several questionnaires and perform neuropsychological tests in collaboration with an experimenter

Interventions

BEHAVIORALSocial interaction

Participants are required to speak to one another. Participants are given various topics of conversation.

Sponsors

Euromov Digital Health in Motion
CollaboratorUNKNOWN
University Hospital, Montpellier
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

Individuals with a diagnosis of schizophrenia : Inclusion Criteria: * diagnosis of schizophrenia according to the DSM-V * being able to read, speak and understand french * giving eclaired consent

Exclusion criteria

* history of head trauma * history of neurological conditions (epilespsy, multiple sclerosis, parkinson's disease, amyotrophic lateral sclerosis, huntington's disease, stroke) * substance use * pregnant women Healthy controls : Inclusion Criteria: * being able to read, speak and understand french * giving eclaired consent

Design outcomes

Primary

MeasureTime frameDescription
interpersonal synchronization4x6 minutessynchronization between body movements of two interacting partners
intrapersonal synchronization4x6 minutessynchronization between voice and body movements of one individual

Secondary

MeasureTime frame
correlation between primary outcomes and individuals with schizophrenia medications4x6 minutes
correlation between synchronization and willingness to continue the interaction4x6 minutes

Countries

France

Contacts

Primary ContactDelphine Capdevielle, Pr
d-capdevielle@chu-montpellier.fr0467339702
Backup ContactMathilde Parisi
mathilde.parisi99@gmail.com0632935910

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026