Prospective Observational Clinical Study on Changes in Cognitive Levels in Elderly Patients Before and After Hematopoietic Stem Cell Transplantation

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06484049

Enrollment

Registered

2024-07-03

Start date

2024-07-30

Completion date

2026-05-31

Last updated

2024-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hematopoietic Stem Cell Transplantation

Brief summary

Detailed description

To investigate the potential improvement in cognitive levels in elderly individuals following hematopoietic stem cell transplantation, which will help better understand the changes in cognitive levels after transplantation in elderly patients, providing crucial reference for future clinical practice and research. To observe changes in cognitive levels in patients aged ≥55 years receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) before and after allo-HSCT.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

55 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age greater than or equal to 55 years; 2. Patients planning to undergo allogeneic hematopoietic stem cell transplantation.

Exclusion criteria

1. Patients with active diseases; 2. Presence of central nervous system tumor invasion; 3. Planning to undergo two or more transplantations; 4. Severe cognitive impairments or mental illnesses; 5. Inability to communicate in Mandarin.

Design outcomes

Primary

Measure	Time frame	Description
To observe changes in cognitive levels in patients aged ≥55 years receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) before and after allo-HSCT.	1YEAR	1.Post-transplant Assessment: Cognitive level follow-up assessments at 1 month, 3 months, 6 months, and 1 year post-operation. Evaluation content is consistent with pre-transplant assessments. Cerebrospinal fluid testing is scheduled for 3 months post-transplant.4. Survival and Disease Follow-up: Follow-up for one year after transplantation to observe overall survival rate, disease-free survival rate, etc.

Contacts

Primary Contacterlie jiang

jiangerlie@ihcams.ac.cn+86-15122538106

Backup Contactyigeng cao

caoyigeng@ams.ac.cn+86-18622477066

Outcome results