Comparison of Oral Isotretinoin vs Ancomparison of Oral Isotretinoin vs Antibiotics on Corneal Thickness With AV

Comparison of Oral Isotretinoin Versus Ancomparison of Oral Isotretinoin Versus Antibiotics on Corneal Thickness in Patients With Acne Vulgaris

Status

Active, not recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06483971

Enrollment

Registered

2024-07-03

Start date

2023-11-01

Completion date

2024-10-30

Last updated

2024-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cornea

Brief summary

Comparison of Oral Isotretinoin versus comparison of Oral Isotretinoin versus Antibiotics on Corneal Thickness in Patients with Acne Vulgaris

Detailed description

Acne is the most common skin disease requiring attention of health practitioners. It is a self-limiting disease of the pilosebaceous unit, which can lead to devastating and frustrating scars and pigmentary alterations.

Interventions

DIAGNOSTIC_TESTOral Isotretinoin

20 mg/kg/day that affects sebaceous glands and is used to treat severe acne Frequency: Once daily

COMBINATION_PRODUCTAntibiotics

250 mg on laternate day/3 months Frequency: Once or twice daily

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 43 Years

Healthy volunteers

Inclusion criteria

* Patients of either gender shall be enrolled for this study. * Acne vulgaris patients taking oral isotretinoin and oral antibiotics shall be included.

Exclusion criteria

* Patients with any ocular pathology shall be excluded. * Patients with any systemic pathology other than acne vulgaris shall be excluded. * Patients with history of contact lens wear, previous refractive surgery or injury shall be excluded.

Design outcomes

Primary

Measure	Time frame	Description
Optical Coherence Tomography (OCT)	12 Months	Standardized OCT imaging protocols to ensure consistency and accuracy across all measurements.
Snellen Chart	12 months	Visual acuity measured at 3-month and 6-month intervals. Units: Snellen fraction (e.g., 20/20, 20/40)

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026