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Evaluation of the Stability of Sulfur Volatile Compounds From Exhaled Air for Halitosis Diagnosis

Evaluation of the Stability of Volatile Sulfur Compounds in Gas Samples for Halitosis Diagnosis

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06483646
Acronym
HALITOSIX
Enrollment
100
Registered
2024-07-03
Start date
2024-10-01
Completion date
2026-08-01
Last updated
2026-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Halitosis

Brief summary

Halitosis or bad breath is a problem affecting 30% of the world's population. There are many causes, and oral pathologies, including periodontitis, are the main etiology. In order to make a diagnosis, a clinical interview is necessary to distinguish true halitosis from psychological halitosis. In addition, a measurement of volatile sulfur compounds (VSC), the main molecules involved in bad breath, is necessary. This is done during the consultation by measuring the concentration of VSCs in exhaled air. However, few private practices or hospitals have the necessary equipment to measure VSC. As a result, patients are often obliged to travel long distances to obtain a consultation including this specific VSC analysis. The aim of this study is to evaluate the stability of VSC values obtained in gaseous samples up to 7 days after sampling, in order to assess the clinical relevance of analyzing samples at a distance from sampling. The clinical aim is to determine whether self-sampling by the patient at home and extemporaneous analysis could be considered in the diagnosis of halitosis.

Interventions

OTHERGaseous sampling:

the subject is asked to aspirate the gaseous contents of his oral cavity using a 1ml plastic syringe.

Sponsors

University Hospital, Strasbourg, France
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adult, male or female * Subject affiliated with a social health insurance plan * Able to understand the objectives and risks of the research and to give dated and signed informed consent * Subject presenting for consultation for diagnosis and treatment of periodontal pathology

Exclusion criteria

* Subject under safeguard of justice * Subject under guardianship or curatorship * Pregnancy or breast-feeding * Impossibility of giving the subject informed information (subject in emergency situation, difficulties in understanding the subject, etc.) * Subject currently included in another clinical research protocol or in an exclusion period

Design outcomes

Primary

MeasureTime frame
H2S measurementAnalysis will be made at Day 0 and Day 7

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 20, 2026