Acute Kidney Injury, Continuous Venovenous Hemofiltration, Energy Metabolism, Nutrition Therapy, Resting Energy Expenditure
Conditions
Brief summary
The bioenergetic balance is the sum of energy exchanged during CRRT and is mostly defined by citrate glucose and lactate. When CRRT was performed with the older dialysis fluids, glucose and lactate could be an important source of energy next to citrate when used as predilution (6, 7). During continuous venovenous hemofiltration (CVVH), a subgroup of CRRT which is performed with the newer dialysis fluids without lactate or glucose as advocated by the KDIGOguidelines, glucose and in a minor way lactate mostly induce a loss of energy. The first aim is to determine how this bioenergetic balance impacts energy need compared to the measured energy with indirect calorimetry and how nutrition therapy needs to be adapted. Also, disease specific predicting equation have been created for patients suffering from acute kidney injury treated with renal replacement therapy. How this predicting equation and other existing predicting equations agree with the measured REE has not been validated yet. The second aim is to determine how predictive equations correlate with measured REE in patients treated with CVVH.
Interventions
OTHERbioenergetic balance
Bioenergetic balance is calculated for all patients who had a resting energy expenditure measurement with indirect calorimetry.
Sponsors
Universitair Ziekenhuis Brussel
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 130 Years
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the adult ICU (01/01/2021-30/09/2022) * At least one indirect calorimetry measurement (ventilator) or calculation based on harris benedict OR 25Kcal/kg/day * Combined with bio energetic balance measurement * Receiving CVVH during intensive care stay
Exclusion criteria
* Patients admitted outside of the inclusion period will be excluded * The absence of an indirect calorimetry measurement (ventilator) or calculation - based on the Harris Benedict OR 25Kcal/kg/day formula OR The absence of a bio energetic balance measurement * The absence of CVVH during intensive care stay * Pediatric (intensive care unit) patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy | during study completion, on average 4weeks | expressed in Kcal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| resting energy expenditure | during study completion, on average 4weeks | expressed in Kcal |
| protein to energy ratio | during study completion, on average 4weeks | expressed in gr/Kcal |
Countries
Belgium
Outcome results
None listed