Psoriasis
Conditions
Brief summary
Psoriasis lesion is divided into two parts. Half of the lesion will apply cream containing sericin and turmeric and another will apply steroid cream (control). The samples will be apply two times a day for 8 weeks. Psoriasis area and severity index, physician global assessment, body surface area of lesion, dermatology life quality index, Itching score, adverse reaction are evaluated before, after using the samples for 4 and 8 weeks.
Interventions
DRUGSericin extract and turmeric extract cream
Apply the sample 2 times a day for 8 weeks
DRUGTriamcinolone acetonide 1% Cream
Apply the sample 2 times a day for 8 weeks
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age over 18 years * Patients with body surface area of psoriasis lesion less than 10, have psoriasis area and severity index less than 10 , and no lesion at face, hands,feet, and genital area * No topical application on psoriasis lesion at least 2 weeks * Willing to attend the study
Exclusion criteria
* Uncontrolled diseases * Allergic to sericin turmeric and steroid * Other skin diseases * Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Psoriasis Area and Severity Index | 8 weeks | Physician will evaluate the psoriasis lesion using Psoriasis Area and Severity Index. The score is graded 0 to 72 (low score means less severity and high score means high severity). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physician Global Assessment | 8 weeks | Physician will evaluate the psoriasis lesion using Physician Global Assessment score (0 to 6, 0 means completely cleared, except for possible residual nonerythematous discoloration and 6 means condition worsened). |
| Body surface area of lesion | 8 weeks | Physician will evaluate body surface area of psoriasis lesion in percentage. (low percentage means the lesion area decrease and high percentage means the lesion area increase). |
| Dermatology Life Quality Index | 8 weeks | Patients will assess dermatology life quality score (0 to 30, 0 means high life quality and 30 means low life quality). |
| Itching score | 8 weeks | Patients will assess itching score using visual analogue scale (0 to 10, 0 means low severity and 10 means high severity). |
Outcome results
None listed