Antibiotics Affecting Newborn Gut Microbiota
Conditions
Brief summary
Based on a prospective birth cohort, the investigators will collect biological samples from participants including pregnant women and newborns, to measure the gut microbial diversity and metabolites of newborns. These results systematically evaluate the effects of antibiotic exposure on the structure and function of gut microbiota. The project can reveal the effects of antibiotic exposure on the growth and development of gut microbiota in early life.
Interventions
OTHERantibiotic treatment
AT: Mother-infant cohort with antibiotic treatment group CS: Mother-infant cohort (Prophylactic antibiotics therapy) ND: Mother-infant cohort (Natural delivery)
Sponsors
Peking University People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 12 Months
Healthy volunteers
Yes
Inclusion criteria
1. Pregnant woman * aged 20-40 years old * natural conception * single pregnancy * gestational age ≥36 weeks 2. Newborn * normal Apgar score * no serious congenital diseases
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Infant gut microbiome | Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months) | * Diversity of gut microbiota * Abundance of antibiotic resistance genes in gut microbiota * Metabolic pathway of gut microbiota |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Antibiotic treatment | Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months) | * Frequency of antibiotic treatment * Kind and Dose of antibiotic; * Duration of antibiotic use; |
Countries
China
Outcome results
None listed