Cortical Activation, Corticospinal Excitability
Conditions
Brief summary
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.
Interventions
OTHERMotor localizer
Participants were asked to perform arm or foot movements
OTHERMotor imagery
Participants were asked to imagine arm or foot movements.
OTHERAction reading
Participants were asked to read sentences involving arm or foot movements
Sponsors
University of Burgundy
University Hospital, Grenoble
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* persons who have given written consent, * healthy subjects * subjects reading and understanding French * right-handed, * affiliated with a social security system, * between 18 and 40 years old, * had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study.
Exclusion criteria
* Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous, * Regular use of anxiolytics, sedatives, antidepressants, neuroleptics, * Characterized psychiatric pathology, * Ingestion of alcohol prior to the examination, * Persons covered by articles L1121-5 to L1121-8 of the CSP, * Presence of contraindications to MRI or TMS.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of corticospinal excitability | 1 hour and 30 minutes | this is a physiological response obtained by transcranial magnetic pulses (TMS). This is an indicator of the excitability of the motor system, which can be used at rest or during various cognitive tasks (motor imagery or action reading). |
| Cortical activation (BOLD signal) | 1 hour | this is a cortical response obtained via a fMRI. This is an indicator of the brain activity, which can be used at rest or during motor and cognitive tasks (motor imagery or action reading). |
Countries
France
Contacts
Primary ContactLaurent VERCUEIL
Backup ContactWilliam DUPONT
Outcome results
None listed