Placenta Accreta Spectrum
Conditions
Keywords
placenta accreta spectrum disorders
Brief summary
Placenta accreta spectrum (PAS) disorders are pathological attachment of the placenta to myometrium, where trophoblastic cells invade the uterine placental interface. PAS can lead to severe postpartum hemorrhage or even maternal death. Prenatal diagnosis of PAS is essential for optimal obstetric management to improve the pregnancy outcomes. However, in some low resource regions in China, less than 20% PAS are detected before delivery. To explore the feasibility and universality of the bundled prevention and treatment strategy for placenta accreta spectrum disorders in different levels of medical institutions, and to investigate its effectiveness in improving the specialized disease management capabilities of medical institutions at all levels. We will conduct a regional, cluster-randomized trial to assess a multicomponent PAS management strategy to improve the prepartum detection rate of PAS.
Interventions
None listed
Sponsors
National Key Research and Development Program of China
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women who have regular prenatal examination at the research hospitals * Pregnant women diagnosed with PAS before or after delivery
Exclusion criteria
* Pregnant women who have never been diagnosed with placental implantation disease throughout the pregnancy * Pregnant women who were lost to follow-up during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| antepartum diagnosis rate of PAS | through study completion, an average of 1.5 year |
Contacts
Primary ContactJinsong Gao
Outcome results
None listed