Deep Learning, Elective Thoracic Surgery, Pulmonary Function
Conditions
Brief summary
The trial was designed as a single-centre, non-interventional prospective observational study to utilize deep learning technology combined with computed tomography (CT) images to precisely predict the pulmonary function indicators of thoracic surgery preoperative patients.
Detailed description
Preoperative pulmonary function tests are crucial in assessing perioperative complications or mortality risks and providing decision support for thoracic surgery. However, traditional pulmonary function assessment methods have significant limitations, including long testing durations, difficulties in patient cooperation, high false-negative rates, and numerous contraindications. Thus, our study optimized the final model based on 1500 single inspiratory phase CTs by transferring model parameters trained on 500 dual-phase respiratory CTs, enhancing its predictive capabilities for pulmonary function. This adjustment suits real-world application demands, offering more convenient, comprehensive, and personalized preoperative pulmonary function assessment support. Our study optimized the final model based on 1500 single inspiratory phase CTs by transferring model parameters trained on 500 dual-phase respiratory CTs, enhancing its predictive capabilities for pulmonary function. This adjustment suits real-world application demands, offering more convenient, comprehensive, and personalized preoperative pulmonary function assessment support.
Interventions
OTHERSingle inspiratory phase computed tomography.
Utilizing deep learning technology in conjunction with single inspiratory phase computed tomography images to accurately predict the pulmonary function indicators of preoperative thoracic surgery patients.
OTHERRespiratory dual-phase computed tomography.
Utilizing deep learning technology in conjunction with respiratory dual-phase computed tomography images to accurately predict the pulmonary function indicators of preoperative thoracic surgery patients.
Sponsors
GE Healthcare
The First Affiliated Hospital of Guangzhou Medical University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* (1) Signing of the informed consent form; * (2) Male or female, aged 18-75 years; * (3) Undergoing elective thoracic surgery; * (4) Good preoperative pulmonary function cooperation and complete reporting; * (5) Preoperative chest single/dual phase CT scans without significant artefacts and with complete imaging; * (6) The interval between preoperative pulmonary function and single/dual phase CT scans does not exceed one month.
Exclusion criteria
* (1) Poor preoperative pulmonary function cooperation or missing reports; * (2) Preoperative chest single/dual phase CT scans exhibit significant artefacts or image omission; * (3) The interval between preoperative pulmonary function and single/dual phase CT scans exceeds one month; * (4) Complication with severe respiratory disorders (such as lung transplantation, pneumothorax, giant bullae, etc.); * (5) Coexisting with other severe functional impairments; * (6) Patients with obstructive lesions such as airway or esophageal stenosis; * (7) Height beyond the predicted equation range (Female \< 1.45m; Male \< 1.55m); * (8) Medication use before pulmonary function testing that does not meet the cessation guidelines; * (9) Pulmonary function report quality graded D-F.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean Absolute Error（MAE） | 2 years | Used to assess the discrepancy between pulmonary function predictions made by the deep learning algorithm and actual results obtained from pulmonary function tests (measured with a spirometer). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concordance Correlation Coefficient（CCC） | 2 years | Used to assess the discrepancy between pulmonary function predictions made by the deep learning algorithm and actual results obtained from pulmonary function tests (measured with a spirometer). |
Countries
China
Contacts
Primary ContactJianxing He, MD
Outcome results
None listed