Myocardial Stiffness
Conditions
Brief summary
The purpose of this research is to study postmenopausal female masters athletes to see if they will show greater myocardial stiffness and reduced exercise capacity than premenopausal females and similarly aged male masters athletes.
Interventions
DIAGNOSTIC_TESTStress Echocardiogram
Exercise testing via treadmill with simultaneous gas exchange analysis and pre- and post-exercise transthoracic echocardiography.
DIAGNOSTIC_TESTCardiovascular Magnetic Imaging (cMRI)
Non-invasive imaging scan used to examine function and structure of the heart
DIAGNOSTIC_TESTCardiac Magnetic Resonance Elastography (cMRE)
Non-invasive imaging scan used to measure myocardial stiffness
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Longstanding history of competitive endurance athletic performance defined as \>15 years of continuous athletic training for at least 7 hours per week and ongoing engagement in competitive events.
Exclusion criteria
* A current or prior diagnosis of cardiovascular disease as defined by the presence of structural heart disease, heart failure, symptomatic coronary artery disease, more than moderate valve disease or prior valve surgery, * Current or recent pregnancy within 1 year * Positive pregnancy test (study visit 1) * Concurrent or use within 1 year of oral contraceptives or hormone replacement therapy, * Unable to undergo a cMRI (Please refer standard clinical contraindications for MRI)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial stiffness | Day 14 | Myocardial stiffness will be measured by magnetic resonance elastography (kPa) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricular filling pressures with exercise | Baseline | Left ventricular filling pressures with exercise will be measured by stress echocardiography |
| Exercise capacity | Baseline | Exercise capacity will be measured by stress echocardiography |
Countries
United States
Outcome results
None listed