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Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat

Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06475339
Enrollment
24
Registered
2024-06-26
Start date
2024-11-01
Completion date
2027-03-01
Last updated
2026-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatigue; Heat, Hyperthermia

Brief summary

The overall goal of this project is to identify a work/rest cycle that allows for faster mission completion needed in emergency situations, compared to current Army heat guidance, while mitigating heat strain and neuromuscular fatigue. This project will determine the trade-off between faster mission completion and risk of heat strain and physical performance decrements. Completion of this project will allow military leaders to make informed decisions by understanding the impact of their choices on the magnitude of physical performance decrements and expected heat casualties, setting up hot weather missions for success.

Interventions

OTHER30/30 work/rest cycle

Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 30 minutes of work followed by 30 minutes of rest.

OTHER30/20 work/rest cycle

Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 30 minutes of work followed by 20 minutes of rest.

OTHER40/30 work/rest cycle

Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 40 minutes of work followed by 30 minutes of rest.

OTHER20/12 work/rest cycle

Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 20 minutes of work followed by 12 minutes of rest.

Sponsors

State University of New York at Buffalo
Lead SponsorOTHER
United States Department of Defense
CollaboratorFED

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 39 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy individuals * Physically active

Exclusion criteria

* History of cardiovascular, metabolic (such as clinical thyroid disease), respiratory, neural, or renal disease * Hypertensive (systolic blood pressure \> 139 mmHg, diastolic blood pressure \> 89 mmHg) or tachycardic (heart rate \> 100 bpm) during the screening visit * Taking medications or supplements known to effect physiologic responses to exercise or thermoregulation (e.g., beta blockers, omega-3 fatty acids, statins, aspirin) * Tobacco or nicotine use currently or in the past six months * Musculoskeletal injury expected to impact exercise in the protocol * A positive pregnancy test at any point in the study * Study physician discretion based on any other medical condition or medication * Inability to understand or follow instructions or the protocol * Gastrointestinal disease or previous surgery prohibiting core temperature capsule use. Participants with a contraindication can opt to insert the pill rectally as a suppository.

Design outcomes

Primary

MeasureTime frameDescription
Core temperature180 minutes of workMaximum gastrointestinal temperature reached during the work protocol
Isometric mid-thigh pull strength180 minutes of workMaximum voluntary contraction strength assessed using a force plate

Secondary

MeasureTime frameDescription
Metabolic cost180 minutes of workCollected expired air using a one-way mask will be analyzed using a metabolic cart to calculate metabolic heat production
Heart rate180 minutes of workMaximum heart rate measured using a telemetry strap throughout the work protocol
Mean skin temperature180 minutes of workMaximum skin temperature measured using buttons at four skin sites
Vastus lateralis electromyography180 minutes of workWireless electromyography electrodes placed lengthwise over the vastus lateralis muscle belly

Countries

United States

Contacts

CONTACTRiana R Pryor, PhD
rpryor@buffalo.edu7168295456
PRINCIPAL_INVESTIGATORRiana R Pryor, PhD

University at Buffalo

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026