Residual Embolism Evaluated With Single Photon Emission Computed Tomography

Residual Embolism Evaluated With Single Photon Emission Computed Tomography - The RESPECT Cohort

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06473610

Acronym

RESPECT

Enrollment

358

Registered

2024-06-25

Start date

2024-06-27

Completion date

2026-04-30

Last updated

2025-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Circulation Obstruction

Keywords

scintigraphy

Brief summary

Major progress achieved in diagnostic and therapeutic strategies has substantially improved the short-term prognosis of patients with pulmonary embolism (PE). These improvements have led to a shift from an acute to a chronic condition of venous thromboembolism, justifying the recent development of Chronic Thrombo-embolic Disease (CTED). In most of the situations, it is due to a residual pulmonary vascular obstruction (RPVO) which can be assessed by pulmonary scintigraphy.

Detailed description

Planar ventilation/perfusion (V/Q) scintigraphy is the gold standard, but for several months, V/Q single photon emission computed tomography (SPECT) is recommended in the guidelines. The aim of this study is to evaluate the performances of various SPECT protocols to quantified RPVO and compared to planar scintigraphy to evaluate the RPVO.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient addressed to nuclear medicine department of Saint-Etienne public hospital for V/Q pulmonary SPECT-CT assess to rule out perfusion obstruction, admitted for a suspicion of pulmonary hypertension (PH), or a persistent dyspnea after PE * Patient affiliated ou beneficiary of social security.

Exclusion criteria

* Pregnant patient. * Patient addressed to nuclear medicine department for acute pulmonary embolism. * Impossibility of the entire protocol acquisitions realization.

Design outcomes

Primary

Measure	Time frame	Description
RPVO (%)	At inclusion	Evaluation of the RPVO establish with Meyer score (planar scintigraphy, 2D). The higher the percentage, the greater the obstruction of the lung
Segmental visual score	At inclusion	Evaluation of segmental visual score (SPECT-CT , 3D) The higher the percentage, the greater the obstruction of the lung

Countries

France

Contacts

Primary ContactPierre-Benoit BONNEFOY, MD

pierre-benoit.bonnefoy@chu-st-etienne.fr(0)4 77 82 94 43

Backup ContactNATHALIE PREVOT, MD

nathalie.prevot@chu-st-etienne.fr(0)4 77 82 94 43

Outcome results