Vaccines
Conditions
Keywords
Kenya, Uganda, Vaccine coverage, Vaccine completion, Vaccine timeliness, Digital health interventions
Brief summary
The research team of investigators from University of Michigan and the African Population and Health Research Center will implement and evaluate a newly-developed digital vaccine card and accompanying mobile application and electronic immunization registry. This will take place in rural Uganda and urban Kenya Health and Demographic Surveillance Systems (HDSS) and the study team will analyze its feasibility, impacts, cost through process, and economic evaluations. The study team will also assess the data quality and equity of the digital vaccine registry and card system.
Detailed description
This study design has three parts or aims for this project, however, only the third aim is considered to be the trial portion and is included in this registration.
Interventions
OTHERSMS reminders for upcoming vaccination(s)
All parents/caregivers of children in participating villages will receive access to a digital vaccine card. This will be used for record-keeping application (digital vaccine registry). Selected parents/caregivers of children will receive SMS messages and reminders related to vaccination.
Sponsors
African Population and Health Research Center
University of Michigan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Intervention model description
Mothers will be randomized to receive the digital vaccine card access with short message service (SMS) reminders versus mothers who did not receive digital vaccine card access with SMS reminders (treatment/control).
Eligibility
Sex/Gender
ALL
Age
1 Days to 24 Months
Healthy volunteers
No
Inclusion criteria
* 1 day to 24 months old
Exclusion criteria
* Sites not included in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diphtheria, pertussis, and tetanus first dose (DPT1) coverage | 18 months of the intervention period | Percent (%) of all children born in the intervention period that received the first dose of DPT vaccine (Continuous measure, 0-100%). |
| Diphtheria, pertussis, and tetanus first dose (DPT3) coverage | 15 months of the intervention period (last 15 months of the intervention period) | Percent of all children born in the first 15 months of the intervention period that received the third dose of DPT vaccine (Continuous measure, 0-100%). |
| Dropout rate from DPT1 to DPT3 | 15 months of the intervention period (last 15 months of the intervention period) | Difference in the proportion of children born in the first 15 months of the intervention period that received the first and third doses of the DPT vaccine (Continuous measure, 0-100%) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dropout rate from DPT1 to Measles | 9 months of the intervention period (second half of the intervention) | Difference in the proportion of children born in first 9 months of the intervention period that received the first dose of the DPT vaccine and the Measles vaccine (Continuous measure, 0-100%) |
| Timeliness of BCG vaccination | 18 months of the intervention period (full intervention period) | Percent of all children born in the intervention period that received the BCG vaccine by 4 weeks (Continuous measure, 0-100%). |
| Measles coverage | 9 months of the intervention period (second half of the intervention) | Percent of all children born in the first 9 months of the intervention period that received the Measles vaccine (Continuous measure, 0-100%). |
| Timeliness of DPT3 vaccination | 15 months of the intervention period (last 15 months of the intervention period) | Percent of all children born in the intervention period that received the third dose of DPT vaccine by 18 weeks (Continuous measure, 0-100%). |
| Timeliness of Measles vaccination | 9 months of the intervention period (second half of the intervention) | Percent of all children born in the intervention period that received the Measles vaccine by 10 months (Continuous measure, 0-100%). |
| Timeliness of DPT1 vaccination | 15 months of the intervention period (last 15 months of the intervention period) | Percent of all children born in the intervention period that received the first dose of DPT vaccine by 10 weeks (Continuous measure, 0-100%). |
| Bacillus Calmette-Guerin (BCG) coverage | 18 months of the intervention period (full intervention period) | Percent of all children born in the intervention period that received the BCG vaccine (Continuous measure, 0-100%). |
| Completion of basic immunizations | 9 months of the intervention period (second half of the intervention) | Percent of all children born in the first 9 months of the intervention period that received all basic recommended immunizations (BCG, oral polio vaccine (OPV), DPT1, DPT2, DPT3, OPV1, OPV2, OPV3, Pneumococcal Conjugate (PCV)1, PCV2, PCV3, rotavirus (Rota)1, Rota2, Rota3, Measles) |
Countries
Kenya, Uganda
Outcome results
None listed