Two-level ESPB in Total Knee Arthroplasty

Two-level Erector Spinae vs iPack With ACB Plane Block in Total Knee Arthroplasty

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06470542

Enrollment

Registered

2024-06-24

Start date

2024-11-07

Completion date

2025-08-05

Last updated

2025-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Arthritis, Knee Osteoarthritis, Knee Pain Chronic

Brief summary

Effect of two-level ESPB in Total Knee Arthroplasty

Detailed description

Knee arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. Patients may complain of severe pain due to surgical trauma and prostheses. Regional anaesthesia methods may be performed to reduce the inflammatory response, opioid consumption, and opioid-related side effects.

Interventions

DRUG2 x 20 ml of Ropivacaine 0.2% Injectable Solution

2 x 20ml 0.2% Ropivacaine - ultrasound-guided iPACK + ACB

DRUG2 x 20ml of Ropivacaine 0.2% Injectable Solution

2 x 20ml 0.2% ropivacaine - ultrasound-guided ESPB at the L1 and S1 level

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

65 Years to 100 Years

Healthy volunteers

Inclusion criteria

* patients scheduled for total hip arthroplasty * patients aged \>65 and \<100 years * patients able to provide informed consent * patients able to reliably report symptoms to the research team

Exclusion criteria

* inability to provide first-party consent due to cognitive impairment or a language barrier

Design outcomes

Primary

Measure	Time frame	Description
Total Opioid Consumption	48 hours after surgery	Total opioid consumption after surgery - within 48 hours after surgery

Secondary

Measure	Time frame	Description
Time to first rescue opioid analgesia	48 hours after surgery	Time after surgery when the patient needs opiate for the first time
Numerical Rating Scale [range 0:10]	8 hours after surgery	Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)
NLR	24 hours after surgery	neutrophil-to-lymphocyte ratio
PLR	24 hours after surgery	platelet-to-lymphocyte ratio
Quadriceps muscle strength assessed using medical research council scale [range 0:5]	4 hours after surgery	Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026