Laparoscopy, Neuromuscular Blockade
Conditions
Keywords
Neuromuscular block, Recovery, Laparoscopic hysterectomy
Brief summary
BACKGROUND: Some studies have revealed that deep neuromuscular block (NMB) improve surgical conditions and alleviated postoperative pain compared with moderate NMB. The present study investigated deep NMB could improve the quality of recovery after laparoscopic hysterectomy METHODS: seventy-two women with elective laparoscopic hysterectomy were randomly divided into 2 groups: Patients in group A received low-pressure pneumoperitoneum (LPP), which was set at 8-10 mmHg with deep NMB. Patients in group B received standard-pressure pneumoperitoneum (SPP), which was set at 12-14 mmHg with moderate NMB. Primary outcome was the quality of recovery (QoR-15) at 1 day after sugery. The secondary outcomes included postoperative pain, surgical condition, incidence of shoulder pain, the incidence of rescue analgesic drug use, cumulative dose of analgesics, time of first flatus, post-operative nausea and vomiting, time of tracheal tube removal.
Interventions
low-pressure pneumoperitoneum (LPP) with deep NMB.
standard-pressure pneumoperitoneum (SPP) with moderate NMB.
Sponsors
Anqing Municipal Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists (ASA) physical status Ⅰ- Ⅲ * Scheduled for elective laparoscopic hysterectomy
Exclusion criteria
* Inability to give informed consent * BMI \>35 * Renal or hepatic insufficiency * History of preoperative psychiatric * Previous surgery at procedure site * Neuromuscular disease, pregnancy, and contraindications to study medications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of recovery | 1 day after operation | Primary outcome measure was the quality of recovery at 1 day after surgery. Quality of recovery-15 scale was used to assess the quality of recovery after operation. A higher score of quality of recovery-15 scale indicates a better quality of recovery after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Shoulder pain | The first 24 hours after operation | Secondary Outcome Measure was the incidence of shoulder pain |
| Postoperative nausea and vomiting | The first 24 hours after operation | Secondary Outcome Measure was the incidence of postoperative nausea and vomiting. PONV score was evaluated verbally with a descriptive scale (0 = None, 1 = Mild Nausea, 2 = Moderate Nausea, 3 = One Vomiting, 4 = Multiple Vomiting). |
Countries
China
Contacts
Primary ContactXu si qi, Doctor
Outcome results
None listed