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Appendicoliths in Acute Complicated Appendicitis Patients With Abscess

Clinical Significance of Appendicoliths in Conservative Treatment of Acute Complicated Appendicitis Patients With Abscess: A Single-center Retrospective Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06469086
Enrollment
100
Registered
2024-06-21
Start date
2025-01-01
Completion date
2026-12-31
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Complicated Appendicitis With Abscess

Brief summary

Complicated appendicitis, characterized by the presence of an abscess or perforation, involves acute inflammation of the peritoneum secondary to an infection of the appendix, presenting additional challenges for management. Traditionally, the standard treatment for complicated appendicitis has been surgical intervention. However, conservative management, involving antibiotics and drainage, has emerged as a viable alternative for selected patients. Recent studies emphasize the importance of selecting appropriate antibiotics based on local resistance patterns and the patient's clinical condition. Broad-spectrum antibiotics, including those targeting anaerobic bacteria, are often preferred. In addition, advances in imaging technology, such as ultrasound-guided drainage, have improved the precision and success rates of percutaneous abscess drainage. This minimally invasive approach helps manage localized infections and can prevent the need for immediate surgery. One factor that has gained significant attention in determining the success of conservative treatment for acute complicated appendicitis is the presence of appendicoliths-calcified deposits within the appendix. This study aims to investigate the clinical significance of appendicoliths in the conservative management of acute complicated appendicitis with abscesses.

Interventions

The clinical significance of appendicoliths in the conservative management of acute complicated appendicitis with abscesses.

Sponsors

Shanghai Zhongshan Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

* Patients who aged ≥18 years, who diagnosed as acute appendicitis clinically, who had peri-appendiceal abscess larger than 2 cm in diameter on CT scan, who agreed conservative treatment first, who refused immediate emergency surgery

Exclusion criteria

* Patients younger than 18 years, those with malignancies, those with incomplete clinical or pathological records were excluded from the study

Design outcomes

Primary

MeasureTime frame
The success rate of conservative treatmentJanuary 01, 2025 to December 31, 2025.

Secondary

MeasureTime frame
Postoperative complicationsJanuary 01, 2025 to December 31, 2025.
Length of postoperative hospital stayJanuary 01, 2025 to December 31, 2025.
The surgical approach usedJanuary 01, 2025 to December 31, 2025.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026