AML
Conditions
Brief summary
Patients diagnosed with acute myeloid leukemia in the Second Hospital of Shanxi Medical University were selected and divided into the newly diagnosed group, the relapsed group, the complete remission group as the experimental group, and the healthy physical examination subjects as the control group. The relationship between IL-1β, catecholamine and norkephalin in peripheral blood of the experimental group and the control group was observed. According to the literature, the experimental group was significantly higher than the control group. In the experimental group, the newly diagnosed group was higher than the relapse group, and the relapse group was higher than the complete remission group, and the correlation was positive, and the difference was statistically significant.
Interventions
DIAGNOSTIC_TESTEnzyme-linked immunosorbent assay
Serum N/OFQ , IL-1β and NE levels were detected.
Sponsors
Second Hospital of Shanxi Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* In accordance with adult acute myeloid leukemia (non-acute promyelocytic leukemia)The diagnostic criteria for AML in the Chinese Diagnosis and Treatment Guidelines (2017 edition); ②Leukocyte count ≤ 25×109/L; * No treatment has been received in the past 6 months. * None of the candidates are related and known this study, and sign the informed consent.
Exclusion criteria
* Patients who are allergic to the drugs used in this study; * People with mental illness or cognitive impairment; * Patients with infectious diseases; ④Patients with severe heart, liver, kidney and other organ function lesions; ⑤ Combined with other malignant swelling. The tumor.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| N/OFQ | 24 hours | Serum N/OFQ levels |
| IL-1β | 24 hours | Serum IL-1β levels |
| NE | 24 hours | Serum NE levels |
Countries
China
Outcome results
None listed