Birth Asphyxia
Conditions
Brief summary
Children's Hospital Multan is a tertiary care teaching hospital in South Punjab, the poorest and most backward area of Punjab, Pakistan, where a significant number of newborns suffer from birth asphyxia. Therefore, this study was planned with the objective of investigating the effectiveness of magnesium sulphate in severe birth asphyxia, hypothesizing that in cases of birth asphyxia, neonates who are treated with magnesium sulphate have a higher sucking reflex than those who are not treated with magnesium sulphate.
Interventions
Magnesium sulphate 24 hours apart by intravenous infusion at 250 mg/kg/dose (0.5 mL/kg/dose of injection magnesium sulphate 50% w/v diluted in 5 mL/kg of 5% glucose) over a duration of half an hour by an infusion pump
Sponsors
RESnTEC, Institute of Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Hours to 6 Hours
Healthy volunteers
No
Inclusion criteria
* Full-term babies (≥37 weeks of gestation) * Both genders * Severe birth asphyxia * Admitted within six hours of life.
Exclusion criteria
* Premature babies * Congenital malformations * Babies born to mothers who received general anesthesia * Babies whose mothers received magnesium sulfate, pethidine, and other drugs in the past 7 days.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy | 72 hours | Efficacy was labeled as yes if the infant was placed in the supine position, the index finger was placed in the infant's mouth, and the power of sucking movements was judged after 5 seconds, and If the sucking reflex appeared. Efficacy was termed no otherwise. |
Countries
Pakistan
Outcome results
None listed