Causes, Characteristics and Treatment of Hypercalcemia in the Emergency Room of a German Hospital

Retrospective Analysis of Causes, Clinical Presentation and Treatment in Patients With Hypercalcaemia in the Emergency Department of a Tertiary German Hospital

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06467877

Enrollment

200

Registered

2024-06-21

Start date

2010-01-01

Completion date

2025-12-31

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypercalcemia

Keywords

hypercalcemia, calcium, emergency room, mortality

Brief summary

Patients with hypercalcemia were identified in the patient population of a German emergency department during a 11 year time period and studied regarding reproducibility of elevated calcium values, causes of hypercalcemia, symptoms. acute renal injury, mortality and treatment response.

Detailed description

Patients, who presented to the emergency department of a tertiary German hospital with a total calcium of ≥2.65 mmol/l between January 2010 and March 2021, was retrospectively studied. From the electronic patient records we analyzed if the elevated calcium values were reproducible in follow-up measurements, identified the cause of hypercalcemia, listed the symptoms, investigated a correlation between calcium and creatinine values to study acute renal injury directly due to hypercalcemia, calculated the mortality rate stratified by the calcium value on presentation and studied the treatment response regarding lowering calcium values by different treatments.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 years * Total calcium ≥ 2.65 mmol/l * Female and male

Exclusion criteria

* Age \< 18 years * Total calcium \< 2.65 mmol/

Design outcomes

Primary

Measure	Time frame	Description
Development of total calcium values	5 days after enrollment	Overview of total calcium values within 5 days

Secondary

Measure	Time frame	Description
Reproducibility of elevated calcium values	5 days after enrollment	Determination of cause of hypercalcemia, of symptoms, of treatment response. In dependence of hospital stay, kann be determined later than 5 days after enrollment
Correlation creatinine calcium	5 days after enrollment	Determination of correlation between calcium and creatinine.
Mortality	5 days after enrollment	occurence of death within of 5 days after enrollment

Countries

Germany

Outcome results