Frontal Lobe Epilepsy, Others Subtypes, Temporal Lobe Epilepsy
Conditions
Keywords
Attentional control, Focal epilepsy, Event related potentials, Functionnal connectivity, high-resolution EEG
Brief summary
Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.
Interventions
OTHERAll included subjects
Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.
Sponsors
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age superior to 18 and under 80 * Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up * Normal global cognitive performance (standard progressive Raven matrices score \> 5th percentile) * Be affiliated to the social security system * Have signed an informed consent
Exclusion criteria
* Pregnancy or breastfeeding * Not able to give consent (Article 1121-8 of the CSP) * Vulnerable person * Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) * Guardianship * Have a high probability of not respecting the protocol or of abandoning the study * Absence of any epileptic seizure recorded during the hospitalization * Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Subtest of divided attention of the Test of Attentional Performance (TAP) | 24 hours | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| N200 amplitude and latency | 24 hours | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. |
| Strength of EEG functionnal connectivity during an attentional task (global and regional) | 24 hours | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. |
| Variation of power in several frequency bands (theta, alpha and beta) during an attentional task. | 24 hours | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. |
| Magnetic resonance imaging functional connectivity. | up to 5 days | — |
| Differences in N200 and P300 amplitude and latency recorded between different subgroups according to the epileptic focus. | 24 hours | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. |
| P300 amplitude and latency | 24 hours | A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure. |
| Differences in strength of EEG functional connectivity during an attentional task recorded between different subgroups according to the epileptic focus. | 24 hours | — |
| Differences in variation of power in several frequency bands (theta, alpha and beta) during an attentional task recorded between different subgroups according to the epileptic focus. | 24 hours | — |
| Differences in magnetic resonance imaging functional connectivity recorded between different subgroups according to the epileptic focus. | 24 hours | — |
Countries
France
Outcome results
None listed