Ankle Surgery, Foot Surgery, Popliteal Nerve Block, Post Operative Pain
Conditions
Brief summary
This study aims to understand the ideal formulation to utilize in saphenous nerve and popliteal nerve blocks for foot and ankle procedures. It will examine the use of liposomal bupivacaine alone or liposomal bupivacaine with dexamethasone prior to foot and ankle procedures in peripheral nerve blocks. We will compare liposomal bupivacaine (Exparel) and liposomal bupivacaine (Exparel) combined with dexamethasone to determine if the addition of dexamethasone significantly decreases postoperative narcotic use and prolongs analgesic effects when administered in a popliteal and saphenous block prior to foot and ankle orthopedic procedures.
Interventions
20 mL Liposomal bupivacaine (Exparel, 266 mg) will be administered in the popliteal and saphenous block
DRUGBupivacaine Hcl 0.75% Inj
10 mL of 0.75% bupivacaine will be administered in popliteal and saphenous block
DRUGDexamethasone
1 mL of 10 mg Dexamethasone will be administered in the popliteal and saphenous block
Sponsors
Rothman Institute Orthopaedics
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participants with foot and ankle procedures at Jefferson Surgery Center, Navy Yard * Participants with foot and ankle orthopedic procedures requiring a preoperative nerve block * Age 18 and older * English speaking * Ability to complete surveys by phone or in person * Ability to provide informed consent
Exclusion criteria
* Revision foot and ankle cases * Allergies to study medications * Non-English speakers * Known alcohol or narcotic abuse history * Existing contract with a pain specialist due to underlying preoperative pain syndrome * Preoperative opioid use within the 3 months prior to surgery * Participants who are pregnant, plan to become pregnant, or are breastfeeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of pain medication used after surgery | 14 days | Collected as tablets taken since all participants will be prescribed oxycodone |
| Pain level after surgery | 14 days | Participants will be asked daily what their pain levels are using the Visual Analog (VAS) pain scale |
Countries
United States
Outcome results
None listed