To Compare the Efficacy and Safety of Hybrid ESD and ESD in the Treatment of Colorectal LST
Conditions
Keywords
Colorectal adenoma；Laterally spreading tumors, Endoscopic submucosal dissection, Hybrid endoscopic submucosal dissection
Brief summary
This study will retrospectively include LST patients who were admitted to 6 medical centers (The Second Affiliated Hospital, College of Medicine, Zhejiang University; The Affiliated Jinhua Hospital, Zhejiang University School of Medicine; First Affiliated Hospital of Huzhou University; The Second Hospital of Jiaxing; Jinhua People's Hospital; Lanxi People's Hospital) from 2020.05.01 to 2023.04.30 with the purpose of comparing the efficacy and safety of hybrid ESD and ESD in the treatment of colorectal LST. The complete resection rate, operation time, operation cost, intraoperative and postoperative complications of hybrid ESD and ESD LST will be compared. To provide strong evidence for the selection of endoscopic treatment strategies for LST.
Interventions
PROCEDUREConventional ESD
Conventional ESD is the most suitable method for total resection, especially for large lesions. This method can complete the resection of early gastrointestinal cancer and precancerous lesions, while maintaining the integrity of digestive tract anatomy and physiological function.The operation difficulty of this technique is high, the equipment requirements are high, the operation time is long, and the complication rate is closely related to the technical level of the operator.
PROCEDUREHybrid ESD
Hybrid ESD is a better choice, but only can remove the lesion in one piece, but also has a lower technical difficulty than conventional ESD
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years old; * LST lesion diameter \>1cm; * Medical record data integrity
Exclusion criteria
* Pedicle lesions; * Resection of residual lesions after endoscopic treatment; * Advanced endoscopic imaging showed submucosal infiltrating lesions. * The lesions are in patients with inflammatory bowel disease; * Familial polyposis; * Electrolyte abnormalities; * Coagulation dysfunction; * Pregnant or lactating patients; * Taking nonsteroidal anti-inflammatory drugs or anticoagulants; * A history of alcoholism; * Severe organ failure; * Medical records are incomplete
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| complete resection rate | 2 weeks | One-time complete excision |
Countries
China
Outcome results
None listed