Arthroplasty Shoulder, Periprosthetic Joint Infection
Conditions
Keywords
periprosthetic joint infection, cutibacterium, shoulder arthroplasty, chlorhexidine
Brief summary
The goal of this interventional study is to determine the amount of skin C. acnes reduction with increased pressure during the chlorhexidine gluconate, brand name ChloraPrep, application. The main question it aims to answer is: Does changing the pressure applied during the ChloraPrep application impact the amount of C. acnes bacteria on the skin after one hour? Researchers will compare ChloraPrep applied at a pressure similar to a gentle wipe to ChloraPrep applied at a pressure similar to a massage to see if wash the amount of C. acnes on the skin after one hour is different. Participants will have one shoulder washed with ChloraPrep using pressure meant to impact the dermal layer, similar to a gentle wipe, and the other shoulder washed with ChloraPrep using pressure meant to impact the subdermal layer, similar to a massage. Participants will have swabs taken of their skin before the ChloraPrep application and again one hour after application to look for the amount of C. acnes on the skin.
Interventions
DRUGChlorhexidine Gluconate
Test Group: the participant's shoulder skin will be treated by the study team with the standard chlorhexidine wash at lower pressure (similar to a gentle wipe) for 30 seconds Control Group: the participant's shoulder skin will be treated by the study team with the standard chlorhexidine wash at higher pressure (similar to a massage) for 30 seconds
Sponsors
University of Washington
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Randomization Option 1: Right shoulder, Test Group ; Left shoulder, Control Group Randomization Option 2: Right shoulder, Control Group ; Left shoulder, Test Group
Eligibility
Sex/Gender
MALE
Age
18 Years to 89 Years
Healthy volunteers
Yes
Inclusion criteria
* English speaking
Exclusion criteria
* Self report very sensitive skin * Allergic to chlorhexidine * Used antibiotics in the last three months * Used acne treatment in the last three months * Wounds on your shoulders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Quadrants on Culture Plate of Cutibacterium Growth After ChloraPrep Application with Dermal Pressure | 60 Minutes After ChloraPrep Wash |
| Number of Quadrants on Culture Plate of Cutibacterium Growth After ChloraPrep Application with Subdermal Pressure | 60 Minutes After ChloraPrep Wash |
Countries
United States
Contacts
Primary ContactAnastasia Whitson
Outcome results
None listed