Association Between Renal Resistive Index(RRI) and AKI(Acute Kidney Injury) in Cardiac Surgery Patients With Cardiopulmonary Bypass (CPB)

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06464666

Enrollment

250

Registered

2024-06-18

Start date

2024-07-01

Completion date

2025-06-30

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Renal Resistive Index

Brief summary

AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity. The conventiional marker for detecting AKI is serum creatinine, however, which has many limits. RRI(Renal Resistive Index) is a non-invasive test measured by ultrasound and could be a useful tool to evaulate renal insult in the early phase. Early detection of renal insult and prevention of progression to AKI can contribute to reduing mortality and morbidity in cardiac surgical patients.

Interventions

PROCEDURERenal interlobar artery US

By using convex US transducer, first find interlobar artery. Then get a pulsed wave doppler at renal interlobar artery for similar 3 to 5 waveforms. Measure peak systolic and minimum diastolic velocity and calculate RRI value.

PROCEDURERenal inter-lobular artery US

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Aged 19 years and older scheduled for cardiac surgery using CPB

Exclusion criteria

* Emergency opeartion, pre-operative shock status requiring vasopressor or inotropics, s/p kidney transplant patients, CKD stage 4 and 5 patients, patients who have renal artery stenosis or history of renal artery stent implantation, patients who have ascites with Child-Pugh classification B or C, In case of CPB weaning failure, In case of poor lung function and PaO2 or PaCO2 cannot be maintained within normal range.

Design outcomes

Primary

Measure	Time frame	Description
post-operative AKI incidence	within first 1 week after surgery	The definition of AKI refers to Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury.

Secondary

Measure	Time frame	Description
Major adverse kidney outcome (MAKE) 30	within first 1 month after surgery	MAKE30 includes new dialysis, eGFR decrease more than 25% from the baseline, and mortality

Contacts

Primary ContactSUNGMIN SUH, MD

suh5701@yuhs.ac82-10-8916-5701

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026