Acute Coronary Syndrome, Angina, Stable, Coronary Artery Disease Premature, MINOCA, Myocardial Infarction
Conditions
Keywords
Air pollution, young, Coronary Artery Disease Premature
Brief summary
The new global guidelines from the World Health Organization on air quality provide evidence of the damage that air pollution inflicts on human health at even lower concentrations than previously thought. Different studies have shown an increase in the incidence of coronary artery disease (CAD) in young people in recent decades. The main objective of this project is to study the impact of environmental pollutants on the premature manifestation of CAD from different epidemiological approaches and their impact on the evolution of these patients with a gender perspective. It is a retrospective analytical case-control study nested in a cohort of patients ≤40 years old with a clinical history of CAD including: ST-segment elevation myocardial infarction, non-ST-segment elevation acute coronary syndrome, unstable angina, stable angina or silent angina according to the international classification of diseases.
Interventions
None listed
Sponsors
Fundacin Biomedica Galicia Sur
Conselleria de Saúde Pública de Galicia
Conselleria de Medio Ambiente, Territorio e Vivenda de Galicia
pablo Juan-Salvadores
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
CASES: Inclusion Criteria: * Women and men between 18 and 40 years old with a diagnosis of coronary artery disease coded in their medical records in Galicia
Exclusion criteria
* Not having a postal code and primary care center assigned in their medical records in Galicia CONTROL Inclusion Criteria: * Women and men between 18 and 40 years old with no diagnosis or history of CAD or other coronary disease coded in their medical records
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To determine the differences in exposure to environmental pollutants in patients ≤40 years old with and without coronary artery disease | 15 years | The study will measure the levels of environmental pollutants (such as PM2.5, PM10, nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3), among others) in patients ≤40 years old with a clinical diagnosis of coronary artery disease and in patients without a diagnosis of coronary artery disease, in order to compare the differences. |
| To evaluate the impact of environmental pollutants on the incidence of the combined variable of major adverse cardiovascular events (MACE) up to 1, 5, and 10 years from the index cas | 15 years | To evaluate the impact of environmental pollutants on the incidence of the combined variable of major adverse cardiovascular events (MACE) up to 1, 5, and 10 years from the index cas |
| To describe the prevalence of CAD in patients ≤40 years old in Galicia | 15 years | To describe the prevalence of CAD in patients ≤40 years old in Galicia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To identify the impact of temperatures on early CAD by age and sex. | 15 years | The study will determine the impact of extreme temperatures, both heat and cold, on the premature presentation of coronary artery disease, by comparing this exposure between patients with and without the disease and sex. |
| To determine the correlation of environmental pollutants in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). | 15 years | To determine the correlation of environmental pollutants in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). |
| To evaluate the influence of PM2.5 and PM10 particles on the early manifestation of CAD. | 15 years | The study will measure the levels of PM2.5, PM10 in patients ≤40 years old with a clinical diagnosis of coronary artery disease and in patients without a diagnosis of coronary artery disease, in order to compare the differences. |
| To evaluate the incidence of serious adverse events | 15 years | To evaluate the incidence of recurrent myocardial infarction, revascularizations (unplanned after admission), stroke, death, major bleeding (BARC scale 2 or higher), hospital admission for stable angina, unstable angina, acute coronary syndrome with or without ST elevation, congestive heart failure (CHF), or heart transplant during 1, 5, and 10 years. By age and sex. |
| To compare the effect of environmental pollutants and their relationship with CAD between men and women. | 15 years | The influence of different environmental pollutants on the premature presentation of coronary artery disease will be analyzed, taking into account the differences between women and men. |
| To describe the prevalence of ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), benzene (C6H6), carbon monoxide (CO), and heavy metals such as arsenic, cadmium, nickel, and lead in the premature manifestation of CAD. | 15 years | To describe the prevalence of ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), benzene (C6H6), carbon monoxide (CO), and heavy metals such as arsenic, cadmium, nickel, and lead in the premature manifestation of CAD. |
| To determine the correlation of noise pollution with premature CAD by age and sex. | 15 years | To determine the correlation of noise pollution with premature CAD by age and sex. |
Countries
Spain
Contacts
Primary ContactPablo Juan-Salvadores, Pharma, PhD
Backup ContactVictor A Jiménez-Diaz, MD, MPH
Outcome results
None listed