Fetal Macrosomatia, Hyperlipidemias, Lipid Metabolism Disorders
Conditions
Keywords
Fetal macrosomia, Nulliparous, Triglyceride, TyG index
Brief summary
Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus. The triglyceride level and other lipids increase slightly during pregnancy. This increase has a positive effect on the development of the fetus. However, an excessive increase in lipid levels can cause some metabolic disorders such as gestational diabetes and increase feto-maternal morbidity/mortality. While some existing studies have shown that elevated triglyceride levels can cause fetal macrosomia, others have found no correlation between these two variables. The ratio of triglycerides to HDL is a widely used marker for lipid disorders. In addition, the triglyceride-glucose index is also an index used to detect insulin resistance.
Detailed description
In this study, the investigators aimed to investigate whether the ratio of triglycerides to high-density lipoprotein cholesterol and the triglyceride glucose index are associated with fetal macrosomia in low-risk nulliparous pregnant women.
Interventions
OTHERTyG index
association between TyG index and triglyceride to high-density lipoprotein cholesterol ratio with fetal macrosomia
Sponsors
Ankara Etlik City Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Screening for fetal macrosomia was based on the term defined according to the standards of the American College of Obstetricians and Gynecologists (ACOG). * Low-risk nulliparous singleton pregnant women. * Age between 18 and 40 years old
Exclusion criteria
* Post-term pregnancies * Hospitalized for preterm labor or preterm premature rupture of membranes. * Gestational diabetes mellitus, diabetes mellitus type I - type II. * Pregnant women with fetal growth restriction, hypertensive pregnancy disorders, familial hypercholesterolemia and hyperlipidemia. * Multiparous pregnant women * Multiple pregnancies * Pregnant women with chronic diseases. * Pregnant women with impaired liver function; * Pregnant women with body mass index \<25 and \>40 kg/m2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The TyG index | between 28 and 40 weeks of pregnancy | The triglyceride-glucose index was determined using the formula Ln \[fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2\], with blood samples taken from pregnant women in the third trimester. |
| The triglyceride to high density lipoprotein cholesterol ratio | between 28 and 40 weeks of pregnancy | The triglyceride to high density lipoprotein cholesterol ratio was calculated from the blood samples taken from pregnant women in the third trimester. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HOMA-IR | between 28 and 40 weeks of pregnancy | HOMA-IR was calculated according to the formula: fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5 with blood samples taken from pregnant women in the third trimester. |
Countries
Turkey (Türkiye)
Outcome results
None listed