Refractory Juvenile Idiopathic Arthritis (Despite 2 DMARDs Still Active)
Conditions
Brief summary
Interventional phase 3 study aiming to unravel the value of pulse steroids in achieving remission or low disease activity in refractory active JIA
Detailed description
First group will receive 2 consecutive days intravenous pulse of 125 mg methylprednisolone. Second group will not receive additional drugs. Assessment was done at baseline and every month for 3 months for both groups using Juvenile Arthritis Disease Activity Score (JADAS) and the American College of Rheumatology Pediatric 30, 50, and 70 response criteria (ACR Pedi. 30, 50, 70).
Interventions
DRUGSolumedrol
2 days pulse steroid injection 125 mg methylrednisolone
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
2 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Patients still active despite administration o 2 DMARDs
Exclusion criteria
* Other connective tissue diseases * Endocrine disorders such as Thyroid disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| remission or low disease activity | 3 months | patients will be assessed at baseline and every month for 3 months using Juvenile Arthritis Disease Activity Score (JADAS) for disease activity American College of Rheumatology Pediatric 30, 50, and 70 (ACR Pedi. 30, 50, 70) for disease activity |
Countries
Egypt
Outcome results
None listed