Assessment of Microfragmented Adipose Tissue Loaded on Bovine Graft Versus Bovine Graft Only on Ridge Preservation.

Radiographic and Histomorphometric Assessment of Microfragmented Adipose Tissue Loaded on Bovine Graft on Ridge Preservation Versus Bovine Graft Only for Subsequent Implant Placement in the Maxillary Posterior Region, a Randomized Clinical Trial.

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06457867

Enrollment

Registered

2024-06-13

Start date

2024-07-01

Completion date

2025-03-01

Last updated

2024-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Mobility

Keywords

unrestorable caries lesions or affected periodontium.

Brief summary

Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by Radiographic and Histomorphometry) utilizing microfragmented adipose tissue loaded on bovine graft versus bovine graft only for maxillary posterior ridge preservation.

Detailed description

All patients involved in this study will be divided into two groups; each group will receive a different graft of bone augmentation: Adipose tissue loaded on bovine graft will be utilized for the study group and bovine raft only for the control group. After 6 months, patients will be evaluated histomorphometrically via core biopsy at the time of implant placement and radiographically via assessment of ridge height on CBCT. Radiographic assessment that will be achieved by CBCT scan will be used to calculate the changes of bone height from base line (1week) to 6 months postoperatively.

Interventions

PROCEDUREmicrofragmented adipose tissue loaded on bovine graft

microfragmented adipose tissue loaded on bovine graft on ridge preservation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

21 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients requiring implant treatment after tooth extraction due to either unrestorable caries lesions or affected periodontium. * Age group: above 21 years * Remaining natural teeth have good periodontal tissue support and occlusion showed sufficient inter arch space for future prosthesis.

Exclusion criteria

* General contraindications to implant surgery. * Subjected to irradiation in the head and neck area less than 1 year before implantation. * Poor oral hygiene and motivation. * Severe bruxism or clenching. * Systemic, immunologic, or debilitating diseases that could affect normal bone healing & local pathosis. * Treated or under treatment of intravenous amino bisphosphonates. * Active infection or severe inflammation in the area intended for implant placement. * Patients participating in other studies if the present protocol could not be properly followed. * Heavy smokers

Design outcomes

Primary

Measure	Time frame	Description
Quantity of bone (vertical bone height)	Quantity of bone (vertical bone height) by CBCT after 6 months	By CBCT

Secondary

Measure	Time frame	Description
Quality of bone	Histological analysis (Core biopsy) Percentage of newly formed bone after 6 months	Histological analysis (Core biopsy) Percentage of newly formed bone

Contacts

Primary ContactBshaer Bayashot, BDS

bshaer.bayashot@dentistry.cu.edu.eg01064825199

Backup ContactHesham Elhawary, prof

hesham.elhawary@dentistry.cu.edu.eg01144446373

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026