Healthy Aging
Conditions
Keywords
Nutritional intervention, Glucose monitoring, Reduced carb diet, Energy metabolism, Ketones
Brief summary
The present study will evaluate the effects on glucose, ketones and other blood biomarkers, cognition, quality of life, physical activity and well-being of a reduced carbohydrate diet paired with a ketogenic product for 2 months in a population living in a senior residence. This study follows the KetoHome (fall 2022) and SAGE (fall 2023) projects which assessed the feasibility, acceptability and effectiveness of a reduced carbohydrate intervention alone.
Interventions
DIETARY_SUPPLEMENTreduced carbohydrate menu combined with ketogenic supplement
Participants will eat a reduced carb menu for 2 months and they will take 15g of MCT in the morning and the evening for a total of 30g per day.
Sponsors
Nestlé Health Science
Université de Sherbrooke
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Participants will be compared to themselve (i.e. pre-intervention and post-intervention) The intervention will be 2 months of reduced carbohydrate menu combined with a ketogenic supplement (MCT)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Older men or women in a senior residence; * Understand, read and write French; * Have sufficient visual and hearing acuity to pass cognitive tests; * Available during the intervention period
Exclusion criteria
* Body mass index \< 20; * T1 diabetic; * T2 insulin-dependent diabetic; * MMSE \< 20; * Weight loss \>10% in the last 6 months involuntary or voluntary; * Known and uncontrolled hypoglycemia; * Moderate to severe digestive illnesses that can be aggravated by dietary changes; * Severe dysphagia; * Supplementation with MCT oil, ketone salts, ketone esters, adherence to the ketogenic diet, reduced carbohydrate diet, intermittent fasting or other diet or supplements that can significantly increase ketones in the last month; * Participation in other interventional research projects on nutrition or aimed at metabolic change simultaneously. * Medical condition that could prevent the participant from completing the study in the opinion of the doctor
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma glucose concentration | 2 months | To evaluate the possible improvement in mean glucose concentration following a reduction in carbohydrates combined with an MCT supplement in people living in a senoir residence for 2 months. |
| Plasma ketones concentration | 2 months | To evaluate the possible improvement in mean ketones concentration following a reduction in carbohydrates combined with an MCT supplement in people living in a senoir residence for 2 months. |
| Plasma insulin concentration | 2 months | To evaluate the possible improvement in mean insulin concentration following a reduction in carbohydrates combined with an MCT supplement in people living in a senoir residence for 2 months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma triglycerides concentration | 2 months | To evaluate the possible improvement in mean triglycerides concentration following a reduction in carbohydrates combined with an MCT supplement in people living in a senoir residence for 2 months. |
| Plasma cholesterol concentration | 2 months | To evaluate the possible improvement in mean cholesterol concentration following a reduction in carbohydrates combined with an MCT supplement in people living in a senoir residence for 2 months. |
Countries
Canada
Contacts
Primary ContactCamille Vandenberghe
Outcome results
None listed