Amphetamine Use Disorders
Conditions
Brief summary
Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes the effect of closed-loop tACS based on brain states
Detailed description
Methamphetamine use disorder (MUD) addiction represents a severe public health concern. Individuals addicted to methamphetamine exhibit intense cravings and physiological reactions when exposed to addiction-related cues, a phenomenon termed "cue reactivity." Cue reactivity is a critical factor in the development and persistence of addiction. Impairments in inhibitory control are considered a significant factor contributing to the emergence of cue reactivity. Conventional pharmacological and physical interventions suffer from low efficiency and high effect variance. Closed-loop physical interventions, which adjust stimulation parameters in real-time based on brain state, are an innovative approach with the potential to enhance the precision and efficiency of treatments. Closed-loop interventions based on transcranial alternating current stimulation (tACS) hold promise as a novel therapeutic method for treating methamphetamine addiction. This study aims to develop and evaluate the effect of closed-loop tACS on cue reactivity and inhibition control function in MUD. Therefore, the investigators intend to employ the non-invasive tACS technique, predicated upon biomarkers of addiction states, to administer specific frequency stimulations to targeted brain regions, aiming to achieve therapeutic objectives in addiction treatment.
Interventions
We conducted a longitudinal controlled study of closed-loop tACS interventions among MA dependents.This involved implementing interventions based on addiction-induced states.
Sponsors
Shanghai Mental Health Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
Individuals aged between 18 and 55 years, irrespective of gender, having completed a minimum of 9 years of education or are capable of effectively cooperating in questionnaire evaluations. Meet the diagnostic criteria set forth by the DSM-5 concerning the severity of amphetamine-type substance addiction. A history of utilizing amphetamine-type substances for a duration not less than one year, with a frequency of use of at least once per week. Consent to actively cooperate in the completion of subsequent follow-up assessments.
Exclusion criteria
Severe cognitive functional impairments manifested through a history of head trauma, cerebrovascular diseases, epilepsy, etc., or usage of cognitive enhancement drugs in the past 6 months; an intellectual disability with an IQ score less than 70. A diagnosis of schizophrenia or other severe mental illnesses as per the DSM-5 criteria. Abuse or dependence on other psychoactive substances (excluding nicotine) within the past 5 years. Severe organic diseases that might compromise study participation. Contraindications to tACS, include a history of epileptic seizures or the presence of metallic implants in proximity to the head.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Analog Scale for craving (VAS-Craving) | through study completion, an average of 5 days | The intensity of psychological craving in MA dependents was assessed using the Visual Analogue Scale for craving (VAS-Craving), where individuals rated their cravings on a scale from 0 to 100, with higher scores indicating greater levels of craving. The VAS scores were utilized based on two conditions: during a resting state and when subjected to cue induction involving images associated with methamphetamine, serving as the criteria for evaluation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stop-signal task | through study completion, an average of 5 days | The stop-signal task can indicate executive control capabilities by measuring Stop-signal reaction time (SSRT), Stop-signal delays (SSD), Go-task reaction time (RT), and Success and failure inhibition rates. A lower SSRT value indicates better inhibitory control. |
| Obsessive Compulsive Drug Use Scale (OCDUS) | through study completion, an average of 5 days | The Obsessive Compulsive Drug Use Scale (OCDUS) measures the overall craving level within a period from a multidimensional perspective. The scale consists of 13 items and uses a five-point scoring system, with each item scored on a scale of 1 to 5. The higher the total score, the greater the level of craving. |
Countries
China
Contacts
STUDY_CHAIRMIn Zhao
Shanghai Mental Health Center
Outcome results
None listed