Association Between Euploid Embryo Grade and Maternal Age

Association Between Euploid Embryo Grade and Maternal Age, a Retrospective Cross-sectional Study

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06454058

Enrollment

502

Registered

2024-06-12

Start date

2024-06-07

Completion date

2025-03-26

Last updated

2025-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility

Keywords

Advanced Maternal Age, Embryo Grade

Brief summary

Background: Advanced maternal age (AMA) is associated with a reduction in live birth rate (LBR) after ART cycles. The main reason for this reduction is the lower number of oocytes aspirated, the number of developing embryos and the low number of euploid embryos available for transfer. The impact of age on success rates after the transfer of an euploid embryo has been a matter of discussion, with a recent meta-analysis showing a reduction in LBR after the transfer of an euploid blastocyst to women of AMA (1). There could be many reasons for this reduced LBR but they can be categorized into two broad categories - the uterus (including the mother's health) and the embryo (including the oocyte and the sperm). It is possible that factors associated with reduced embryo quality would manifest in a lower embryo grade.

Detailed description

Objective: To study if there is an association between advanced maternal age and lower embryo grading of euploid embryos. Hypothesis: Advanced maternal age is associated with a lower embryonic grade in euploid embryos. Study Design: This is a retrospective cross-sectional study of euploid embryos from patients who have completed IVF with PGT-A testing at a fertility clinic in The Prelude Network (US sites only). A comparison of embryo grade between different age groups (\<35, 40+) will be done after controlling for baseline demographic characteristics.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* Patients who have completed IVF egg retrieval with PGT-A testing at a fertility clinic in The Prelude Network (US clinics, excluding NYU) * PGT biopsy was conducted in 2023, * PGT biopsy was performed on blastocyst stage embryo, * PGT-A result is euploid.

Exclusion criteria

* PGT-A result is mosaic, * Embryos in which PGT-M was done and were found to be carriers of the mutation, * Embryos in which PGT-SR was done and were found to be carriers of the structural rearrangement.

Design outcomes

Primary

Measure	Time frame	Description
Embryo Grade	6 months	Embryo grade for PGT-A confirmed euploid embryos

Countries

United States

Outcome results