Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06453252

Enrollment

150

Registered

2024-06-11

Start date

2024-08-01

Completion date

2026-06-30

Last updated

2024-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracranial Atherosclerosis, Posterior Circulation Brain Infarction, Stroke, Ischemic

Brief summary

Early identification of intracranial atherosclerotic disease (ICAD) may impact the management of patients undergoing mechanical thrombectomy (MT). The aim of the study is to develop and validate a scoring system for pre-thrombectomy diagnosis of ICAD in posterior circulation large vessel/distal medium vessel occlusion strokes (LVOs/DMVOs).

Interventions

OTHERwe are aiming to develop a Scoring system based on certain variables derived from both groups

We are aiming to develop a Scoring system based on certain variables derived from both group

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adult ≥18 years 2. Patient with posterior circulation strokes who underwent mechanical thrombectomy.

Exclusion criteria

1. Patients with anterior circulation stroke. 2. Patients with intracranial hemorrhage 3. Patients without baseline radiological data. 4. Extracranial large vessel atherosclerosis related strokes.

Design outcomes

Primary

Measure	Time frame	Description
Post-procedural outcomes included any intracranial hemorrhage, symptomatic ICH (sICH)	June 1st, 2025	sICH is defined as local or remote parenchymal hemorrhage type 2, subarachnoid hemorrhage, and/or intraventricular hemorrhage, combined with a neurological deterioration of 4 points or more on the NIHSS from baseline or leading to death that the physician judged was causative of the deterioration) per ECASS III criteria

Secondary

Measure	Time frame	Description
90 day modified Rankin scale (mRS)	June 1st, 2025	a score of 0 to 4 on the modified Rankin scale (range, 0 to 6, with a score of 0 indicating no disability, 4 moderately severe disability, and 6 death) at 90 days, was changed to a good functional status (a modified Rankin scale score of 0 to 3, with a score of 3 indicating moderate disability)
90 day mortality	June 1st, 2025	—

Countries

Egypt, United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026